Showing papers in "Atherosclerosis in 1994"

TL;DR: Interestingly, the LDL cholesterol to LDL cholesterol ratio and total cholesterol to HDL cholesterol ratio were significantly reduced in CLA-fed rabbits, and Examination of the aortas of CLA- fed rabbits showed less atherosclerosis.

TL;DR: The results of this prospective population-based study do not support the hypotheses that serum homocysteine or Lp(a) are risk factors for atherosclerotic disease and may be due to the exceptionally low gene frequency predisposing to homocysteinemia in Finland.

TL;DR: Analysis of the frequency distributions for the three LDL subfractions revealed the concentration of small, dense LDL-III to be bimodal around a concentration of 100 mg (lipoprotein mass)/100 ml plasma, which could be explained by their primary influence on plasma triglyceride.

TL;DR: The data suggest that small chylomicron remnants are implicated in the progression of coronary artery disease.

TL;DR: Testing the hypothesis that flowfield properties are closely related to the localization of plaques in this segment of the arterial system demonstrates that in the infrarenal aorta, regions of low mean and oscillating wall shear stresses are predisposed to the development of plaque while regions of relatively high wallShear stress tend to be spared.

TL;DR: It is suggested that visceral fat accumulations may play an important role in the occurrence of CAD regardless of obesity.

TL;DR: The new automated computerized edge tracking method presented in this paper represents an advance for image analysis of B-mode ultrasound images of common carotid IMT with measurement variability substantially reduced (2 to 4 times) compared with currently available manual methods.

TL;DR: The data indicate that there may be heterogeneity in these patients with regard to CVD risk, that peripheral neuropathy is a major problem in many patients, and that CVD is a significant clinical problem in middle aged and elderly Tangier homozygotes.

TL;DR: The persistence of multiple cardiovascular risk clustering from childhood to adulthood and the impact of obesity in this regard point to the need for preventive measures aimed at developing healthy lifestyles early in life.

TL;DR: The article summarizes the increased knowledge about the enigmatic Lp(a) lipoprotein and its clinical importance over the past 20 years and suggests that an autoimmune process might especially occur in individuals with inherited high Lp (a) levels and certain HLA class II genotypes, triggered by a concurrent infection.

TL;DR: Small amounts of dietary plant sterols, especially sitostanol esters dissolved in dietary fats, decrease serum total and LDL cholesterol by a proportional decrease in cholesterol absorption which, in turn, is associated with a compensatory increase in cholesterol synthesis.

TL;DR: It is indicated that a subnormal expression-level of the Apoe gene leads to hypercholesterolemia and, consequently, to an increased susceptibility to the development of atherosclerosis.

TL;DR: The data indicate that CETP TaqI B polymorphism is related to plasma CETP activity and HDL cholesterol concentration in non-smoking men, but these associations are affected by smoking and alcohol drinking.

TL;DR: Findings strongly suggest that the presence of these potential genetic risk factors for CHD, namely the epsilon 4 allele of apo E and the R- allele of Apo B, decreases the probability of an individual reaching an extremely old age.

TL;DR: It is shown for the first time that iron ions induce oxidation of the cellular polyunsaturated fatty acids in intact macrophages and that this cellular lipid peroxidation can subsequently induce LDL oxidation.

TL;DR: A brief overview will describe selected altered cell functions of oxidized lipoproteins and how they may impact on atherosclerosis.

TL;DR: It is suggested that conversion of cholesterol into 27-Hydroxycholesterol and 3 beta-hydroxy-5-cholestenoic acid represents a general defence mechanism for macrophages and possibly also other peripheral cells exposed to cholesterol and may contribute to the premature atherosclerosis known to occur in patients with sterol 27-hydroxylase deficiency.

TL;DR: It is suggested that lesion formation may be initiated following the development of arterial wall hypoxia, secondary to excision of the adventitial vasa vasorum, and a novel method to restore a highly vascular 'neoadventitia' to an artery whose adventitia has previously been removed is devised, using loosely placed PVC tubing.

TL;DR: No difference was detected between control subjects and patients concerning vitamin E concentration and the kinetics of conjugated diene formation in isolated LDL exposed to CuSO4, however, vitamin E efficiency was lower and the duration of the vitamin E-independent lag phase was longer.

TL;DR: Estrogen replacement therapy is both likely to be beneficial to female health, pending randomized trials, as well as a tool to understand mechanisms of prevention of coronary artery disease.

TL;DR: The data show that the macrophage-derived immune activation marker neopterin is closely correlated with the extent of carotid atherosclerosis, and chronic activation of immune cells, preferentially of macrophages, may play a key role in atherogenesis and/or progression of Atherosclerosis.

TL;DR: It is shown that CETP demonstrates substrate specificity and that the increase in activity with dietary trans fatty acids may contribute to a more atherogenic lipoprotein profile.

TL;DR: It is concluded that LDL derived from patients with essential hypertension is more susceptible to lipid peroxidation than control LDL, and this may be secondary to angiotensin II stimulation of LDL lipid per oxidation in these patients.

TL;DR: Reference values for the viscosity of blood, plasma, and serum that may assist in evaluating hemorheological profiles are provided and men had significantly higher blood viscosities values than women at each shear rate.

TL;DR: The data strongly suggest that the LPL-Asn9 variant is associated with and may play a direct role in predisposing carriers to develop hypertriglyceridemia.

TL;DR: It is concluded that of the factors considered, LPL contributed the most to the alcohol-induced rise in HDL-C.

TL;DR: The association between DHEAS and the CHD risk was studied using logistic regression analyses with the classical risk factors--age, smoking, blood pressure, and lipid levels--as covariates in the models and it was revealed that the risk associated with elevated DHEas was confirmed to older men.

TL;DR: The results suggest that the monocyte-EC interaction in unstimulated ECs is mediated, in part, by the LFA-1-ICAM-1 pathway and in IL-1 beta-stimulatedECs, in parts, by both LFA and VLA-4-VCam-1 pathways.