Showing papers in "Biosensors and Bioelectronics in 1998"

TL;DR: A biosensor that will measure, at the level of single molecules, the forces that bind DNA-DNA, antibody-antigen, or ligand-receptor pairs together, and the potential to directly gauge intermolecular interaction strengths suggests drug discovery applications.

TL;DR: The engineering approaches and the recent trends in the development of alternative immunoassay systems are overviews and the engineering issues involved in immunosensor development are outlined and trends towards practical applications are discussed.

TL;DR: Using the peptide nucleic acid in the biosensor recognition layer greatly increased the specificity of the DNA hybridization biosensor making it possible to detect point mutations (single-base mismatches) in DNA.

TL;DR: A sensor plasmid was constructed by inserting the regulation unit from the cadA determinant of plasmids pI258 to control the expression of firefly luciferase, capable of replicating in Gram-positive and Gram-negative bacteria.

TL;DR: In this paper, a modular micro chemical analysis system fabricated on silicon wafers using semiconductor technology is presented, which is designed to handle particle containing solutions allowing novel applications in biochemical and cytochemical analysis.

TL;DR: The insulating properties of the different layers of the biosensor were investigated and two different methods using epoxy- or carbodiimide coupling of the polyclonal antibodies were compared.

TL;DR: In this paper, the authors discuss the unique structural, hybridization, and recognition features of PNA probes, along with the opportunities accrued from the use of the PNA recognition layers in DNA diagnostics.

TL;DR: Four different techniques for the immobilisation of proteins onto the gold electrode of a piezoelectric quartz crystal were investigated and adsorption, avidin-biotin binding and two different types of covalent binding on self-assembled monolayers (SAM), dithiobis(succinimidylpropionate) (DSP) and a dextran modified thiol monolayer.

TL;DR: An improved antibody-coated sensor system based on quartz crystal microbalance analysis on Salmonella spp.

TL;DR: A planar array immunosensor, equipped with a charge-coupled device (CCD) as a detector, was used to simultaneously detect 3 toxic analytes and the identity and amount of toxin bound at each location on the slide were determined by quantitative image analysis.

TL;DR: A surface plasmon resonance [SPR] immunosensor demonstrates an increased ability for performing sensitive and selective assay of human immunoglobulin G [hIgG] compared with a device fabricated with a physically-adsorbed IgG-silver interfacial-layer due to reduced levels of non-specific binding.

TL;DR: A separation-free electrochemical immunoassay method for the detection of the pesticide atrazine is described, incorporating disposable screen printed horseradish peroxidase modified electrodes as the detector element in conjunction with single-useAtrazine immuno-membranes.

TL;DR: The present state of the art to record or mimic electronically the human senses of olfaction and taste is characterized and the natural olfactory system is described in detail.

TL;DR: It appears that insect acetylcholinesterase is more susceptible to a broad range of organophosphates and carbamates insecticides than the other tested enzymes.

TL;DR: A sol-gel silicate-based biosensor for glucose was made by utilizing a composite membrane ofsol-gel enzyme film and electrochemically generated poly(1,2-diaminobenzene) film to improve the selectivity of the sol- gel enzyme sensors.

TL;DR: The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases and the kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time.

TL;DR: The microsensor system presented in this paper is a modular arrangement of various planar and non-planar sensor elements surrounding small cell culture chambers that proved to be an effective device both for toxicological and environmental research.

TL;DR: The field of phosphate sensors is reviewed and information provided includes conditions like pH and temperature at which the device is operated, as well as experimental results in the form of linear ranges, detection limits and interfering substances.

TL;DR: The dimer species (M(r) 580,000) of the nicotinic acetylcholine receptor, isolated from the electric organ of Torpedo californica, was incorporated into a thiopeptide supported lipid bilayer by fusion of liposomes with reconstituted receptor onto a gold-backed lipid monolayer.

TL;DR: To fulfill the need for rapid, cost-effective and sensitive methods for the detection of bacteria in medical diagnostics, food technology, biotechnology and environmental monitoring, a development of a bacterial sensor was initiated and a five-fold amplification of the signal has been achieved.

TL;DR: The application of an electrodeposited polytyramine film as an immobilisation matrix for the construction of enzyme biosensors is described and is shown to produce a highly reproducible and stable device.

TL;DR: The in situ potentiostatic electropolymerization of pyrrole (Py) on a Pt electrode in a thin-layer amperometric cell and the entrapment of the enzyme glucose oxidase (GOx) for the determination of glucose are reported.

TL;DR: A glucose amperometric biosensor based on glucose oxidase immobilized on an overoxidized polypyrrole (PPyox) platinum modified electrode, by glutaraldehyde co-crosslinking with bovine serum albumine, is described, showing an apparent Michaelis-Menten constant and excellent interferent rejection of electrosynthesized non-conducting polymers.

TL;DR: A composite polymer, comprising Nafion, m-phenylenediamine, and resorcinol, showed the best selectivity and stability to amperometric NO detection and was shown to capture elevated NO levels in brain following an ischemic injury.

TL;DR: Copolymerization of pyrrole peptides on the chip (leading to peptide chip) and their immunological detection is illustrated and this technology shows a high dimensional resolution and a real versatility.

TL;DR: Data is presented which demonstrate strain improvements appropriate to biosensor technology: improved signal to noise ratio, ease of data collection and uncomplicated material handling.

TL;DR: Two hybrid three-channel multibiosensors for simultaneous amperometric operation in food quality control are presented, i.e. glucose/fructose/ethanol multib biosensor and L-lactate/L-malate/sulfite multIBiosensor.

TL;DR: In this article, an amperometric biosensor for organophosphorus insecticides based on acetylcholinesterase inhibition was studied, where an enzyme was immobilized on a platinum electrode by entrapment in PVA-SbQ polymer and integrated in a continuous flow system.