Showing papers in "Bone and Mineral in 1987"

TL;DR: The cross-sectional data showed an average diminution in the spine and 25% in the femur between 40 and 70 years of age, followed by a continued but slower, decrease of density in older women.

TL;DR: Comparative studies must be done using bone biopsies to determine more precisely the effects of weightlessness on the human skeleton, as a decrease in mineralization rate and an increase in bone resorption activity were found in both studies.

TL;DR: In this paper, the authors examined whether the administration of 1 alpha (OH)-vitamin D3 (1 alpha (D3) could prevent the occurrence of vertebral crush fractures in senile osteoporosis.

TL;DR: It is concluded that in these bone- and dentin-forming cells, alkaline phosphatase activity is expressed before the appearance of Gla proteins, but that both appear before the onset of mineralization.

TL;DR: The data suggest that the loss of trabecular bone is accelerated around the time of the onset of menopause, and slows somewhat thereafter, although continuing to be significant, however, the findings of this study are based on cross-sectional data, and there remains a need for prospective studies of vertebral bone around the Time of Menopause.

TL;DR: It is concluded that the introduction of a basic residue in bisphosphonates may increase affinity for the specific sites on the mineralized matrix that are involved in directing the accession of precursors and their transformation into actively resorbing osteoclasts.

TL;DR: The effect of ICF on osteoblasts is comparable with the effect on fetal growth plate chondrocytes; both cell types respond to ICF by an increase in calcium-phosphate mineral deposition in the matrix.

TL;DR: A role for alkaline phosphatase in organic phosphate induced mineralization is suggested and it is shown that inorganic pyrophosphate may effect mineralization of bone not only by blocking apatite formation but possibly by modulating organic phosphate metabolism.

TL;DR: A much more comprehensive approach to the study of the risk factors for age-related fractures will be necessary to achieve a clear understanding of fracture heterogeneity and to lead to new hypotheses concerning etiology.

TL;DR: Lower osteocalcin levels in alcoholics than in normal individuals of similar age and sex are found, evidence of the influence of alcohol on osteoblasts, which seems to be direct rather than mediated.

TL;DR: The similar localization of the hormone and its receptors in osteoblasts and osteocytes supports the hypothesis of a direct action of 1,25(OH)2D3 in these bone cells, and implies, as postulated for other steroid receptors, that 1, 25(OH), 2D3 receptors occur primarily in the nucleus.

TL;DR: There was a strong positive correlation between MWT and MTPT in trochanteric fractures suggesting that the decreased trabecular thickness in this group is due to decreased osteoblastic apposition.

TL;DR: It is suggested that chondrocytes that appear to be dedifferentiated after serial passages still have the potential to differentiate.

TL;DR: Providing that adequate dosages are adopted, parenteral Cl2MBP and AHButBP may be a useful measure for controlling hypercalcemia in patients with carcinoma.

TL;DR: Assessment of the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo found no changes in serum beta-endorphin, magnesium or erythrocyte magnesium levels after administration of calcitonin by the intranasal route or by injection.

TL;DR: Clinical use of these two drugs demands careful consideration of their differences, and 1(OH)D3 administration resulted in a slow rise in the serum level of 1,25( OH)2D with a relatively low peak level.

TL;DR: If these results represented the situation throughout the skeleton, it is possible that parathyroidectomy may provide some reduction in future risk of fracture in women with primary hyperparathyroidism.

TL;DR: Examination of serum levels of vitamin D metabolites in seven mutations from three species found that serum 1,25-dihydroxyvitamin D is markedly elevated in each, suggesting resistance to this hormone could be a unifying concept to explain the osteoclast heterogeneities in osteopetrosis.

TL;DR: The in vitro effects of dexamethasone on condylar cartilage from normal newborn mice were tested by measuring protein and DNA content, collagen synthesis, prolyl hydroxylase activity, collagen chains and by immunofluorescence the localization of type I and II collagen and fibronectin.

TL;DR: Chondroitin sulfate was added to the medium of periosteal bone-forming cultures and prevented calcium accumulation and thus mineralization in these cultures, suggesting that calcium and phosphate accumulation in bone may be dependent on two different mechanisms.

TL;DR: Findings suggest that ESAF production occurs as a stage in chondrocyte differentiation which is linked with the onset of matrix calcification, and a model is proposed for the control of angiogenesis in the growth plate.

TL;DR: It is concluded that in patients with renal failure, an increase in circulating osteocalcin by a relatively constant portion reflects decreased renal clearance, and any additional increase in osteoccin serum level indicates an increased skeletal production of osteocalin.

TL;DR: The results support the concept that SP-I is responsible for stabilization of PTH within the secretory granules.

TL;DR: It is concluded that calcium supplementation has no additive effect to estrogen therapy in the prevention of the early postmenopausal bone loss.

TL;DR: Recent data provide the first firm bases for some proposed functions of secretory protein-I that include a regulator of a novel protease capable of converting prohormones to hormones, a hormone precursor, and through its calcium-binding and aggregating properties, a secretory granule condensing protein.

TL;DR: The data indicate that mononuclear cells, cytochemically and functionally resembling osteoclast precursors, may be grown from mouse bone marrow, and CSF-1 inhibited growth of OCP-like cells, indicating that osteoc Last precursor differ from monon nuclear phagocytes in growth requirements.

TL;DR: It is proposed that OCP-like cells are relatively late stages in an osteoclast-specific cell lineage which diverges from the mononuclear phagocyte lineage.

TL;DR: It is interpreted to mean that the mutant skeletal environment is unable to support the development and differentiation of normal osteoclasts, consistent with the failure of toothless rats to be cured by bone marrow transplants from normal littermates.