Showing papers in "Cell Transplantation in 2006"

TL;DR: This case study shows that the implantation of autologous bone marrow cells appears to be safe, as there have been no complications following implantation to date, but longer follow-ups are required to determine that implantation is definitively safe.

TL;DR: Intravenous delivery of human umbilical cord blood cells 48 h after a middle cerebral artery occlusion in a rat resulted in both behavioral and physiological recovery and should offer encouragement to clinicians that a therapy with a broader window of efficacy may soon be available to treat stroke.

TL;DR: It is concluded that multiple administrations of high doses of allogeneic MSCs affected alloreactive immune responses without compromising the overall immune system of recipient baboons and the induction of host T-cell hyporesponsiveness to donor alloantigens may facilitate MSC survival.

TL;DR: It is concluded that UBM facilitates a constructive remodeling of myocardial tissue when used as replacement scaffold for excisional defects.

TL;DR: The multiple hit hypothesis of PD—that is, the effect of more then one risk factor—may be the start of new era in animal models of PD that is one step closer to mimicking the pathology of PD in humans.

TL;DR: It is demonstrated that PuraMatrix™ injection favorably induced functional bone regeneration and induced mature bone tissue while showing cortical bone medullary cavities in a mouse bone defect model of the calvaria.

TL;DR: Small numbers of partially differentiated mouse embryonic stem cells were capable of survival in the deafened mammalian cochlea for up to 4 weeks, without causing an inflammatory tissue response.

TL;DR: In vitro and in vivo studies on the use of bone marrow stromal cells (BMSCs), a heterogeneous cell population that includes mesenchymal stem cells, for repair of the spinal cord in experimental injury models and their potential for human application are reviewed.

TL;DR: The basic research that leads to clinical hepatocytes transplantation, the published clinical experience with this experimental technique, and some possible future uses of hepatocyte transplantation are reviewed.

TL;DR: An overview of different biodegradable scaffolds used, experimental techniques for vessels maturation in vitro under mechanical stimulation, and of differentiated as well as precursors of vascular cells, which opens new opportunities for further development of this form of cell transplantation are provided.

TL;DR: It is demonstrated for the first time that transplantation of MPCs ameliorated motor deficits associated with HI injury and allogeneic transplantation poses as a feasible and efficacious cell replacement strategy with direct clinical application.

TL;DR: Analysis of embryonic transcription factors in adult mouse and human duct cells suggests that the overexpression of transcription factors, especially NeuroD, facilitates pancreatic stem/progenitor cell differentiation into insulin-producing cells.

TL;DR: Evidence that mesenchymal stem cells, by virtue of their renoprotective property, restore renal tubular structure and also ameliorate renal function during experimental acute renal failure provides opportunities for therapeutic intervention.

TL;DR: The development of a fetal skin cell bank is described where from one organ donation it is possible to produce several hundred million fetal skin constructs of 9 × 12 cm2, which are very resistant against physical and oxidative stress when compared to adult skin cells under the same culture conditions.

TL;DR: The present investigations suggest that infarcted myocardium significantly attracts HUCBC, that H UCBC can substantially reduce myocardial infarction size, and that HUC BC can limit the expression of TNF-α, MCP-1, MIP, and INF-?

TL;DR: The long-term durability of agarose microencapsulated islets against autoimmunity in a syngeneic islet transplantation model in NOD mice was evaluated and it was demonstrated that the microcapsules successfully protected the islets from cellular immunity.

TL;DR: In this article, the authors presented a tool to image beta-cell functionality in cell culture and isolated islets and demonstrated a link between image contrast enhancement and β-cell activation in vitro, and provide the basis for future non-invasive in vivo imaging of islet functionality and betacell mass.

TL;DR: Human hepatocytes isolated from untransplantable liver showed the same tendency regarding viability, but cell adherence was not similarly improved by the addition of oligosaccharides, which may be prior cell damage during extended cold ischemia of the human liver, donor age, or cell degradation caused by progression of fatty liver in humans.

TL;DR: The efficient differentiation of hES cells to functional hepatocytes is demonstrated and the findings are useful to develop a bioartificial liver.

TL;DR: This comprehensive review focuses on experience obtained in pig-to-nonhuman primate islet transplantation studies, particularly with regard to the different types of islets and isolation procedures used, and the methods to determine islet viability.

TL;DR: The OCR Index, defined as the ratio of the DNA-normalized “dO2 slope” in high glucose to that in low glucose, proved highly predictive of mouse transplant results, suggesting that the OBS could be a useful tool for the pretransplant assessment of islet cell potency.

TL;DR: The role of primate PD models in the development of novel therapies, such as trophic factor delivery, grafting, and deep brain stimulation, are described.

TL;DR: It is concluded that systemic administration of rat Sertoli cells across xenogenic barrier induces transplantation tolerance without altering systemic immune competence, and data suggest that SERToli cells may be used as a novel and potentially powerful tool in cell transplantation therapy.

TL;DR: The monosyringe repeating dispenser is recommended for myoblast transplantation in skeletal muscles and maybe in the heart, and the multisyringe dispenser accelerated the procedure still more, but it was not ergonomic.

TL;DR: BMSCs have a higher retention when they are injected in necrotic than in normal myocardial areas and these cells appear to stay around the injection site for at least a 7-day period.

TL;DR: This review is an attempt to describe the scientific basis for cardiac cell therapy from the point of view of the clinician, focusing on problems that arise with beginning translation into the clinical setting.

TL;DR: Pancreas weight was found to be positively associated with pre- and postpurification islet yields, and should contribute to the estimation of pancreasWeight, and thus improve donor selection for islet isolation and transplantation.

TL;DR: Activation of the B7-H4 pathway may represent a novel immunotherapeutic approach to inhibit T-cell responses for the prevention of β-cell destruction in T1D.

TL;DR: The results obtained demonstrate that in vitro cultured human mesenchymal stem cells seeded on modified collagen sponges may be able to act as a replacement for soft tissue.

TL;DR: The results demonstrate that the use of a biodegradable polymer-based 3D culture with an appropriate combination of biofactors is a promising approach to maximize functional maturation of hepatocyte progenitors from large animals.