Showing papers in "Hearing Research in 2004"

TL;DR: A loudness model that is applicable to both normal and impaired hearing is described, and can account for the loudness recruitment and reduced loudness summation that are typically associated with cochlear hearing loss.

TL;DR: Smaller auditory dynamic ranges were found in the autistic group than in the control group, as well as increased perception of loudness, indicating hyperacusis in subjects with autism.

TL;DR: In this paper, the effect of DEX against noise-induced trauma, as reflected in hair cell destruction and elevation in auditory brainstem response (ABR) sensitivity, was assessed in guinea pigs, where animals were administered DEX (1, 10, 100, and 1000 ng/ml) or artificial perilymph (AP) via a mini-osmotic pump directly into scala tympani.

TL;DR: These guidelines include: basilar membrane length should be plotted as percent instead of millimeter due to the biological variation that exists in BM length within a particular species and strain, and the total length in millimeter stated on the cochleogram.

TL;DR: Findings of the FFR findings support the viability of early, population-based 'predominant interval' representations of pitch in the auditory brainstem that are based on temporal patterns of phase-locked neural activity.

TL;DR: Findings, i.e., very complex expression patterns of claudin species in the inner ear, would reflect the importance and the complexity of the barrier function of TJs in the outer ear.

TL;DR: It is concluded that loci in addition to ahl contribute to the differences in hearing loss between B6 and CAST mice, illustrating the complex inheritance of age-related hearing loss in mice and may have implications for the study of human presbycusis.

TL;DR: The ability to obtain sequential estimates of tinnitus-like behavior in an animal after administering a tinnitis-inducing agent could aid in understanding the underlying neural mechanisms and assessing potential treatments.

TL;DR: It is discovered that pre-menopausal CBA female mice have healthier OHCs relative to middle-aged males, but much of this relative advantage is lost post-menopause.

TL;DR: The results of the study indicate that the early expansion of cochlear lesion is attributed primarily to apoptosis, whereas the later stage of lesion expansion is likely the result of an equal contribution from apoptosis and necrosis.

TL;DR: Treatment with NAC can prevent CDDP-induced ototoxicity in rats, and the potential chemoprotective effect of administering N-acetylcysteine (NAC) before giving CDDP is tested.

TL;DR: Results suggest that NAC can partially protect the cochlea against impulse noise trauma, and hair cell loss was significantly reduced using a schedule of three NAC injections in the rats.

TL;DR: The present result supports the hypothesis that both spectral and temporal cues contribute to tone recognition and shows that current cochlear-implant subjects produced significantly lower performance than acoustic simulations in normal-hearing subjects, suggesting that neither temporal nor spectral cues have been adequately and appropriately extracted and encoded in current co chlear implants.

TL;DR: A baseline normal response is provided for studies of TM velocity with conductive hearing losses of different etiologies by laser Doppler vibrometry and a second series of measurements was made in subjects with sensorineural hearing loss.

TL;DR: It is confirmed that cisplatin at a daily dose of 2 mg/kg has a detrimental effect on the OHCs as well as on the type-I SGCs and intracochlear effects occur simultaneously; OHC loss and SGC shrinkage appear to develop in parallel.

TL;DR: DeltaVU for the fluid-filled middle ear matched hearing losses reported in patients whose middle ear was believed to be completely filled with fluid, which suggests that the primary mechanism in hearing loss at low frequencies is a reduction of the admittance of the middle-ear air space due to displacement of air with fluid.

TL;DR: In the amygdala, c-fos and arg3.1 IRN were increased substantially after salicylate injections compared to auditory stimulation or saline injections, suggesting that coactivation of the AC and the amygdala may by an essential feature of tinnitus-related activation.

TL;DR: Findings and results of other patients with Tullio phenomenon and superior semicircular canal dehiscence, who also showed lower VEMP threshold, confirmed the theory of a 'third window' that allows volume and pressure displacements, and thus larger deflection of the vestibular sensors, which would cause the Vestibular organ to be more responsive to sound and pressure changes.

TL;DR: Comparison of the 20/s and 120/s stimuli showed that the resulting increase in inhibition was strongest in the center of the STRF, and the common finding was the emergence of an intensity independent bandwidth for the multi-frequency stimuli.

TL;DR: The vibration patterns of the round window (RW) membrane in human cadaver temporal bone specimens were assessed by measurements of the velocity of reflective targets placed on the RW membrane with an approximate spacing of 0.2 mm and by creating animations of the surface vibration at several frequencies.

TL;DR: Inbred strains of mice that are widely used as models of late- (CBA/J and CBA/CaJ) and early- onset age-related hearing loss are examined in terms of the applicability of these animals as tools for examining factors that degrade cochlear function.

TL;DR: This study provides the first physiological and empirical evidence of a link between intolerance to both internal (tinnitus) and external sounds in persons with tinnitus, and is compatible with the clinical observation that severe tinnitis is associated with high stress levels.

TL;DR: Examining gravity receptor function in mutant mouse strains with variable deficits in otoconia shows that behavior alone may be an unreliable indicator of the extent of gravity receptor deficits and underscores the remarkable adaptive potential exhibited by neurobehavioral systems following profound sensory loss.

TL;DR: A novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections separated by 10 days of rest, produced significant hearing loss without mortality and supported the notion that reactive oxygen species are involved in cisPlatin ototoxicity and showed the potential usefulness of antioxidant treatment.

TL;DR: Physiological measurements suggest that the endolymphatic duct may be closed by sustained positive pressure in the vestibule but open during pressure fluctuations, which suggests that the membranous sinus of theendolymphic duct could act as a mechanical valve, limiting the flow of endoly mph from the saccule to the endicalmphatic sac when pressure is applied.

TL;DR: The cochlear-enriched expression of amiloride-sensitive cation channel 3 (ACCN3), a potential candidate for the unidentified mechanoelectrical transduction channel of the sensory hair cells of the cochlea, was confirmed by quantitative real-time polymerase chain reaction.

TL;DR: These experiments confirm that during bone conduction stimulation on the skull, audio-frequency sound pressures can be conveyed by a fluid pathway to the cochlea and stimulate it.

TL;DR: Noise exposure induces A1AR expression, which might be mediated, in part, through generation of reactive oxygen species and activation of NF-kappaB.

TL;DR: The advantage of this combination therapy is that minocycline prevents GM-induced hair cell loss while helping to suppress the bacterial infection.

TL;DR: The trophic actions of IGF-I in the inner ear suggest that this factor may have therapeutic potential for the treatment of hearing loss.