Showing papers in "Human Immunology in 1998"

TL;DR: Most of the newly identified CTL epitopes from TAA were found to be highly crossreactive with other common HLA alleles of the A2 supertype, thus demonstrating their potential in providing broad and non-ethnically biased population coverage.

TL;DR: A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class II microbeads coated with purified HLA antigens using a FITC-conjugated antibody against human IgG.

TL;DR: The results indicate that in addition to the DQ2 heterodimer, the other major risk alleles for CD are DR4 DQ8, and either DQA1*0501 or DQB1*02 alone.

TL;DR: Results imply that interactions between accessory molecule receptor-ligand pairs on primate NK cells, macrophages and porcine endothelium are of critical importance in delayed xenograft rejection.

TL;DR: These studies demonstrate that T suppressor T cells cell lines can be generated by in vitro immunization of human PBMCs, with synthetic peptides or soluble proteins coupled to beads.

TL;DR: TNF genes determine strength, effectiveness, and duration of local and systemic inflammatory reactions, as well as repair and recovery from infectious and toxic agents.

TL;DR: A hinge deletion mutant of IgG3 was found that was reduced in its ability to bind to FcgammaRI and FcGammaRIIa but was more potent at activating ADCC by activated lymphocytes (FcgamMARIIIa-mediated), compared to the wild-type version of Igg3.

TL;DR: Grouping HLA DR alleles into functional categories may assist in understanding the mechanistic basis of autoimmunity, resolving current paradoxes in HLA disease associations, and developing new immunotherapy strategies.

TL;DR: Results suggest that, as in other autoimmune diseases, multiple overlapping susceptibility factors encoded by the MHC complex contribute to the overall susceptibility for the disease, the major factor however, being the presence of the DRB1*0405 allele.

TL;DR: Results indicate that placental sHLA-G is synthesized in trophoblast cells and activated placental macrophages and support the postulate that placenta-derived sHLa-G modulates maternal and fetal immune cell functions during pregnancy.

TL;DR: It is suggested that the potential induction of HLA-G molecules in monocytic malignant cells following secretion of cytokines may constitute a factor of immune tolerance in patients.

TL;DR: HLA-G, a nonclassical class I MHC molecule, is uniquely expressed on extravillous cytotrophoblasts of the maternal- Fetal interface and is suggested to be essential for establishment of maternal-fetal immune tolerance.

TL;DR: It is demonstrated that HLA-G is co-dominantly expressed in first trimester trophoblast cells and a "new" non-synonymous base substitution in exon 4 was detected.

TL;DR: The analyses indicate that the counterbalancing act between susceptible DRB1 and protective DQB1, and vice versa, that has already been observed in Chinese and Japanese, is the major factor responsible for the low incidence of diabetes in Koreans.

TL;DR: In agreement with results obtained in mice there appears to be a hierarchy of DRB1* genes in the HBsAg immune response, which may allow the identification of differences between responsiveness and nonresponsiveness to a few amino acid differences in the beta1-domain of the class II heterodimer.

TL;DR: The results of this study are compatible with previous evidence with mitochondrial (mtDNA) polymorphisms indicating that Amerindians and Na-Dene populations derived from different migrations from Asia.

TL;DR: Results indicate that the peptide substituted for CLIP of Ii p33 bound to the groove of DR molecules in the same manner as CLIP and it was preferentially presented to the CD4+ T cell clone in the absence of HLA-DM molecules.

TL;DR: The T-cell epitopes were mapped in a limited portion of GAD65 protein, with a tendency to be restricted by disease-associated HLA-DR, but not DQ molecules, so that cytotoxicity was not completely dependent on a Fas-Fas ligand interaction.

TL;DR: It was concluded that in the Greek population allele B*5101 is a predisposing marker for Behçet's disease, as in most ethnic groups, and that this allele predisposes to the development of the disease at a younger age in both sexes and to theDevelopment of erythema nodosum.

TL;DR: Evidence is provided that HLA polymorphism may confer a genetic risk or protection for HIV-1 infection in individuals of various ethnic backgrounds and the prevalence of DQ7 and Cw7 was significantly increased in the Black and Hispanic secondary concordant seropositives, respectively in comparison to the seronegatives.

TL;DR: It is shown that self-recognition during the early stages in the development of MS involves HLA-DP class II restricted responses to the PLP 50-63 spreading determinant, and the results suggest thatSelf-presentation by Hla-DP may play an important role in epitope spreading and in the propagation of self- recognition during the clinical progression of MS.

TL;DR: All estimation methods generate reliable haplotype frequencies for the more frequent haplotypes, but are unreliable for the less frequent Haplotype frequency haplotypes.

TL;DR: IgG subclass antibodies to glutamic acid decarboxylase (GAD), a major islet autoantigen in IDDM, are measured in 34 newly-diagnosed IDDM patients and in 28 at-risk, first-degree relatives of people with IDDM to suggest that IgG subclass vaccines to GAD may contribute to diabetes risk assessment in islet antibody relatives.

TL;DR: The data suggest that measurement of plasma IgE and/or cytokines may have prognostic or therapeutic monitoring value in HIV+ patients and a switch from a predominance of type-1 cytokines to type-2 cytokines that may enhance IgE synthesis is suggested.

TL;DR: The result suggests that the MICB gene itself is not responsible for the development of BD, and that the candidate gene(s) for BD is located between the MICA and HLA-C genes.

TL;DR: Evidence is provided that HLA DR2 is an important additional factor for predicting a long term response to interferon-alpha therapy in chronic HCV hepatitis, independent of cirrhosis, which also showed a significant association with response to therapy.

TL;DR: Two different MHC haplotypes resembling the extended haplotypes both contained a non-expressed C4A gene that was due to either of two distinct mutations, demonstrating the heterogeneous genetic background of C4 deficiency.

TL;DR: In this paper, the results demonstrate the impressive advantage of the PCR-SSP method for HLA-A and HLAB locus typing over serological typing in black individuals.

TL;DR: Using short term CTL lines derived from HLA A2/Kb transgenic mice and IFN-gamma release assays, it is demonstrated that the NS4.1769 epitope, is generated from natural processing of theNS4 antigen, and presented in the context of the A2-Kb molecules.