Showing papers in "Journal of Pharmaceutical Analysis in 2016"

TL;DR: An exhaustive list of in vitro antimicrobial susceptibility testing methods and detailed information on their advantages and limitations are reported.

TL;DR: The results indicated that AHDMAPPC can bind to BSA and be effectively transported and eliminated in the body, and can be a useful guideline for further drug design.

TL;DR: Ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.

TL;DR: Microbiological assay is a simple, sensitive, precise and cost effective method which gives reproducible results similar to HPLC; however, the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results.

TL;DR: This study provides a new and promising method for enriching, extracting and determining ampicillin sodium in complex biological samples.

TL;DR: An high performance liquid chromatography-diode array detector (HPLC-DAD) method was established to quantitatively analyze these phytochemicals in different lotus plumule samples and in different part of lotus.

TL;DR: This review presents several typical examples of drug stereoselective metabolism and provides a literature-based evaluation on current chiral analytical techniques to show the significance and challenges of stereOSElectivity assessing methods in drug metabolism.

TL;DR: Ternary system incorporated with ARG performed better than binary system in physicochemical evaluation and could be exploited as a ternary component to improve the physicochemical properties of CFA via βCD complexation.

TL;DR: An efficient and reliable liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for ethanolic root extract of Rauwolfia species is developed to elucidate the fragmentation pathways for dereplication of bioactive MIAs.

TL;DR: The work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach is introduced.

TL;DR: The solid phase extraction and HPLC–UV method enable a specific, sensitive, and reliable simultaneous determination of nine antiretroviral agents in plasma, suitable for use in clinical trials and therapeutic drug monitoring.

TL;DR: It is demonstrated that α-helix content of bHb decreased steadily with the increasing temperature above 35 °C at all pH values, and the loss in α-helicity and gain in random coil conformations was pH-dependent and the greatest under alkaline conditions.

TL;DR: Thermal transition study with the help of differential scanning calorimetry (DSC) shows that the aforesaid active pharmaceutical ingredient (API) is a good glass former.

TL;DR: The dissociation constants of alendronate sodium were determined in this work by studying the piecewise linear relationship between volume of titrant and pH value based on acid-base potentiometric titration reaction.

TL;DR: The study and validation of a method for quantifying intact CTX by reverse-phase high-performance liquid chromatography with diode array detection ((RP)HPLC/DAD) is presented and is demonstrated to be rapid, accurate, and reproducible for CTX quantification.

TL;DR: Hexafluoroisopropanol (HFIP)-induced sodium dodecyl sulfate/dodecyltrimethylammonium bromide (SDS/DTAB) catanionic surfactant coacervate extraction method coupled with high performance liquid chromatography (HPLC) was used to detect the migration of phthalates from disposable tablewares to drinking water.

TL;DR: It is demonstrated that the combined label-free full scan approach is not only able to distinguish between all those different versions of insulin and the insulins originating from different species, but also able to chromatographically separate human insulin and insulin lispro in conditions that are compatible with mass spectrometry (MS).

TL;DR: HPTLC results confirmed that the extract of I. tinctoria contained several potential active components such as phenols, flavonoids, saponins and terpenoids as the slides revealed multi-colored bands of varying intensities.

TL;DR: Ever since Terbinafine was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials.

TL;DR: The results showed that APCI source appeared to be slightly less liable to matrix effect than ESI source, and with an overall consideration, ESI was chosen as a better ionization technique for rapid and sensitive quantification of levonorgestrel.

TL;DR: Boronic acid compounds with different substituted groups were handled to synthesize various ligands encoded as B1, B2, B3, B4, B5, B6, B7 and B8 to demonstrate significant antioxidant activity and these compounds demonstrated as much activity as standards.

TL;DR: The results show that the developed HPLC–FD method is accurate, reliable and will be helpful for preclinical pharmacokinetic study of DOX and PDOX.

TL;DR: The interaction of baicalein with bovine serum albumin (BSA) was investigated with the help of spectroscopic and molecular docking studies and it was observed that the presence of urea ruptured the non-covalent interaction between baicalsein and BSA.

TL;DR: The validated method has been successfully applied to analyze human plasma samples for application in pharmacokinetic studies and demonstrated that the developed method has good precision and accuracy over the concentration ranges of 0.1–2000 ng/mL for each analyte.

TL;DR: The method that was developed generated reproducible results on the dripping behavior of nasal formulations and provided critical information about the compatibility of the formulation with the nasal mucus for different diseased states, aiding in nasal spray formulation development and physical characterization of the nasal spray.

TL;DR: In this article, a single quad mass spectrometry (MS) detector was coupled to a ultra-high performance liquid chromatography (UPLC) system and implemented in the routine quality control (QC) and impurity analysis of four therapeutic peptides, namely bleomycin sulfate, tyrothricin, vancomycin HCl and bacitracin.

TL;DR: It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of (S)-OME without any interference coming from its chiral and achiral related substances.

TL;DR: An improved high performance liquid chromatography--tandem mass spectrometry (LC–MS/MS) method has been developed for sensitive and rapid determination of albendazole (ABZ) and its active metabolite, albENDazole sulfoxide ( ABZSO), in the positive ionization mode and was successfully applied for two separate studies in healthy subjects.

TL;DR: The chemometric optimization and validation of a high performance liquid chromatography method using core–shell particles is presented for the determination of MTX in plasma during therapeutic monitoring, and selectivity, linearity, accuracy and precision were demonstrated.

TL;DR: Ion-pairing high-performance liquid chromatography–ultraviolet (HPLC–UV) methods were developed to determine two commonly used chelating agents, ethylenediaminetetraacetic acid (EDTA) and DTPA, and both methods were successfully utilized in determining the fate of the chelates.