Showing papers in "Lung Cancer in 2004"

TL;DR: This report summarises the epidemiological evidence on the association between tobacco smoking and cancer, which was reviewed by an international group of scientists convened by IARC, and shows a consistent and statistically significant association between exposure to environmental tobacco smoke and lung cancer risk.

TL;DR: Concurrent CRT demonstrated significant benefit in terms of response rate, overall survival and time to progression over sequential CRT in patients with locally advanced NSCLC.

TL;DR: A laser-capture- and microarray-based approach is presented, which comprehensively characterises carcinoma-associated fibroblasts in their in vivo environment for the identification of potential targets for anti-cancer therapy.

TL;DR: Pulmonary nodules which are less than 1cm in size or show GGO images on CT cannot be evaluated accurately by PET, according to this study.

TL;DR: The use of induction chemotherapy to optimize surgical resectability of thymoma followed by radiation therapy and consolidation chemotherapy lead to good control of residual disease and high overall survival rates is believed to prolongs lives and may cure locally advanced unresectable malignant thymomas.

TL;DR: It is concluded that inherited VEGF sequence variations, which characterize the tumor genome itself, are strong determinants of the molecular V EGF and VEGf-downstream phenotype of NSCLC.

TL;DR: It is suggested that the C/C genotype in codon 118 of ERCC1 is a surrogate marker for predicting better survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy.

TL;DR: Treatment with gefitinib in this population of NSCLC patients treated on the EAP study is associated with a longer survival in women, those with good performance status and in patients with adenocarcinomas.

TL;DR: Interestingly, gefitinib appeared to be effective for brain metastases as well as extracranial tumors in patients with refractory NSCLC, confirming previous phase II trial data.

TL;DR: Although gefitinib therapy confers a clinical benefit on patients with advanced NSCLC, especially on women, patients with adenocarcinoma, never-smokers, and patients with no history of thoracic radiotherapy, it also poses a high risk of ILD, especially to patients with pulmonary fibrosis.

TL;DR: Pivanex is well tolerated and appears to be active as a single agent in patients with advanced NSCLC refractory to previous chemotherapy, particularly in combination with current chemotherapeutic agents.

TL;DR: By incorporating FDG-PET in clinical staging, 15% of patients with lung cancer are upstaged due to unexpected extrathoracic metastases.

TL;DR: Second-line docetaxel therapy for advanced NSCLC significantly improves survival with a trend towards less deterioration in QOL compared with BSC, and trends were recorded with QLQ-C30 assessments.

TL;DR: Based on the current available data, and the promising response rates in patients with lung cancer, chemotherapy should be considered for the management of brain metastases as part of a multimodality (or "interdisciplinary") treatment concept.

TL;DR: The current state of the art and future perspectives in detection, staging and standard therapy of small cell lung cancer are summarized, with particular emphasis on concomitant and accelerated radiotherapy and consideration of dose-intensive combination chemotherapy regimens.

TL;DR: The improvement in accuracy and sensitivity with PET suggests bone scan can be eliminated from the staging evaluation at presentation, and a prospective trial with appropriate verification of bony metastases is suggested to confirm the results.

TL;DR: Using the LightCycler RT-PCR assay, the HDAC1 gene expression might correlate with progression of lung cancers, however, further studies are needed to confirm the impact ofHDAC1 for the molecular target of the lung cancer.

TL;DR: Coumarins in combination with other anti-neoplastic drugs might increase the effectiveness of NSCLC treatments and induce apoptosis in patients with non-small cell lung carcinoma cell lines.

TL;DR: This new irradiation technique, utilizing patient-controlled radiation beam switching under self-breath-hold after precise alignment of the isocenter, allows safe high-dose stereotactic radiotherapy with sufficient margins around the CTV and reduced treatment times.

TL;DR: In this paper, the authors examined expression of VEGF and VEGFs in small cell lung cancer (SCLC) cells and their receptors, VEGFR-2 and VegFR-3, in five SCLC cell lines by Western blotting.

TL;DR: Serum YKL-40 (P = 0.02) is independent of prognostic variables for survival within the first 6 months for patients with small cell lung cancer (SCLC), and studies are needed to determine the function of YKl-40 in SCLC.

TL;DR: Although the incidence of BAC has increased over the past two decades, BAC represents less than 4% of all NSCLC in every time period evaluated.

TL;DR: For MPM bidimensional WHO response evaluation cannot automatically be replaced by RECIST because MPM has a non-spherical growth pattern, so the method used in the recently completed pemetrexed (Alimta) trial for MPM is recommended.

TL;DR: The addition of trastuzumab to cisplatin and gemcitabine was well tolerated, but further study will be required to determine whether this combination is superior to chemotherapy alone.

TL;DR: Factors predictive of brain progression could serve as a basis for the selection of patients with the aim of sitting of studies on prophylactic cranial irradiation in NSCLC.

TL;DR: At the 1-year follow-up, more of the subjects receiving Internet-based resources reported making a stop attempt and there were no statistically significant differences in 7-day point prevalence quit rates or advancement in motivational readiness to stop smoking between the groups.

TL;DR: It is demonstrated that exhaled breath condensate may be used for analysis of somatic gene mutations in an area of direct tobacco-related DNA damage, i.e. airways and lung parenchyma.

TL;DR: For peripheral localized bronchioloalveolar carcinoma showing PGGO, wedge resection appears to be the best operation; Definitive study of more patients with longer follow-up is needed.

TL;DR: The overall weighted mean pain prevalence of pain was 47% (range 6-100%).

TL;DR: Complete surgical resection is an independent prognostic parameter in locally advanced thymoma treated with a multimodal approach and preoperative treatment to increase the complete resection rate could improve the overall survival of these patients.