Showing papers in "Microvascular Research in 2000"

TL;DR: This work examined, at the ultrastructural level, microvascular pericyte responses in a well-defined model of traumatic brain injury in the rat, and found migrated pericytes appeared viable and remained in a perivascular location in the adjacent neuropil.

TL;DR: It is suggested that computer-assisted image analysis represents a rapid, objective, and alternative method for the quantitative assessment of tumor angiogenesis and vessel architecture and correlated well with manual microvessel counts and showed significantly less variation.

TL;DR: It is indicated that VEGF affects endothelial transport properties differently depending on the vessel type and that differences in cell signaling pathways underlie the differences in V EGF responsiveness.

TL;DR: Not all VPF/VEGF-secreting tumors induce fenestrated endothelium, and transfer was apparently unnecessary in TA3/St tumors in which extensive early endothelial cell division provided the increased plasma membrane necessary for forming mother vessels.

TL;DR: EMAP-II appears to have important effects on angiogenesis and may play a role in regulating tumor vascular growth and induced endothelial-cell-specific apoptosis via a pathway that includes upregulation of the Fas-associated death domain and downregulation of Bcl-2.

TL;DR: Analysis of distribution patterns of the major vascular gap junction proteins in the murine kidney suggests that the abundance of Cx40-containing gap junctions may be important for coordinating function of cells within individual blood vessels, while their absence in juxtaglomerular regions of the arterioles may prevent conduction of signals between the glomerulus and afferent or efferent arteriols.

TL;DR: The observed morphological changes to RBE4 cells correlated with endogenous Notch4 and Jagged-1 gene activation, demonstrating that Notch signaling can promote endothelial cell differentiation and morphogenesis.

TL;DR: In vivo and in vitro angiogenesis assays using NO donor S-nitroso-N-acetylpenicillamine (SNAP) and NO synthase inhibitor N-iminoethyl- l -ornithine (L-NIO) showed significant changes in capillary ingrowth into subcutaneously implanted Matrigel plugs in mice.

TL;DR: The data demonstrate the morphologic and functional presence of eNOS in the microcirculation and provide evidence that the function of microvascular eN OS is subject to regulation by phosphorylation.

TL;DR: Capillary and arteriolar growth responses in treated animals seem to indicate that the two are independently regulated processes in hearts from stroke-prone spontaneously hypertensive rats.

TL;DR: It is suggested that NO is involved in capillary growth in chronically stimulated muscles possibly via its shear-stress-induced release from capillaries or from interstitial fibroblasts.

TL;DR: SLO imaging of FITC-labeled RBCs in rat retina and choroid provided a reliable method for evaluating normal and abnormal hemodynamics.

TL;DR: Quantitative analysis of vascular generational branching demonstrated that transforming growth factor-beta1 strongly inhibited angiogenesis in the arterial tree of the developing quail chorioallantoic membrane (CAM) by inhibition of the normal increase in the number of new, small vessels.

TL;DR: Heterogeneity between smaller and larger retinal vessels with regard to Ca(2+) mobilisation and homogeneity with respect to the actions of vasoactive peptides are demonstrated.

TL;DR: A mathematical model of drug transport in tissue has been developed on the basis of a clinical study of patients with breast cancer treated with the drug doxorubicin and of drug Transport experiments using cultured human breast cancer cells.

TL;DR: The results broadly supported the concentration-polarization hypothesis, which predicts significant osmotic buffering of drainage at >/=1 mg ml(-1) hyaluronan; at 0.2 mg ml (-1) other factors may predominate, and indicated that this is the critical concentration for molecular domain overlap and intermolecular coupling.

TL;DR: It is concluded that pericytes release a soluble factor or factors that are potent inhibitors of endothelial cell growth and promote vasoconstriction by up-regulating endothelin-1 and down- Regulating iNOS.

TL;DR: Similar to previous in vitro studies with larger vessels, pulmonary arterioles have an attenuated contractile response to PE and hypoxia in sepsis, and there is an increase in both the number of stationary leukocytes and protein leak into the alveolus in the lungs of septic animals.

TL;DR: The results suggest that an enzymatic pathway for cadPR production and metabolism is present along the renal vasculature and that cADPR may importantly contribute to the control of renal vascular tone through CICR.

TL;DR: Findings indicate that RA selectively blocks VPF/VEGF-induced microvascular permeability and angiogenesis and also identify VPF-VEGF as a major target of RA action, which suggests other, RA-independent pathways must exist for the angiogenic response induced by FGF-2 and the vascular permeabilizing effect of histamine.

TL;DR: The findings indicate that topical analgesia influences the myogenic control of the blood flow in those vascular plexa measured by laser Doppler following heat provocation.

TL;DR: There was a discrepancy between changes in capillary number density and skin perfusion, indicating that the perfusion increase does not occur in the capillaries but in the deeper lying vessels and the contribution of the capillary perfusion to the LDF-signal is smaller than previously anticipated.

TL;DR: In this paper, the authors used the kinetics of appearance of a fluorescent tracer in the bloodstream after application to subcutaneously implanted sponges bearing tumor cells to determine angiogenesis and tumor growth in conscious mice.

TL;DR: The results provide evidence that systemic application of Indomethacin leads to vasodilatation of the main arteriole of the villus in the rat ileum and hyperemia in the mucosa in this animal model of intestinal inflammation.

TL;DR: The data indicate that the inward-rectifier K(+) channel was most likely responsible for the K(+)-induced arteriolar dilation in fourth order cremasteric arterioles in the anesthetized rat.

TL;DR: The leukocyte integrins LFA-1 and Mac-1 bind to endothelial intercellular adhesion molecule-1 (ICAM-1), and it is concluded that IC AM-1 is necessary for neutrophil adhesion to unstimulated endothelium, but not for adhesion for cytokine-stimulated endot Helium.

TL;DR: The results indicate a higher hemoglobin content in the skin of the CVI patients than in healthy subjects and a lack of oxygen is unlikely to be the primary reason for the development of skin lesions in CVI.

TL;DR: The approach documented in this paper could be used to address systematically how external loading might affect the transport phenomena in cortical bone.