Journal ArticleDOI
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Yong S. Chang,Lance L. Munn,Mechteld V. Hillsley,Randal O. Dull,Jin Yuan,Sunitha Lakshminarayanan,Thomas W. Gardner,Rakesh K. Jain,John M. Tarbell +8 more
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TLDR
It is indicated that VEGF affects endothelial transport properties differently depending on the vessel type and that differences in cell signaling pathways underlie the differences in V EGF responsiveness.About:
This article is published in Microvascular Research.The article was published on 2000-03-01. It has received 132 citations till now. The article focuses on the topics: Vascular endothelial growth factor A & Vascular permeability.read more
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Cytoskeletal regulation of pulmonary vascular permeability
Steven M. Dudek,Joe G.N. Garcia +1 more
TL;DR: The critical role of the endothelial cytoskeleton in integrating these multiple aspects of pulmonary vascular permeability provides a fertile area for the development of clinically important barrier-modulating therapies.
Journal ArticleDOI
Pathophysiological consequences of VEGF-induced vascular permeability
Sara M. Weis,David A. Cheresh +1 more
TL;DR: By blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells.
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Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
TL;DR: Using a mathematical model to simulate IFP and IFV profiles in tumors, it is shown that antiangiogenic therapy can decrease IFP by decreasing the tumor size, vascular hydraulic permeability, and/or the surface area per unit tissue volume of tumor vessels.
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Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Saroja Ramanujan,Alain Pluen,Trevor D. McKee,Trevor D. McKee,Edward B. Brown,Yves Boucher,Rakesh K. Jain,Rakesh K. Jain +7 more
TL;DR: Comparison of diffusion and convection data in these gels and tumors suggests that collagen may obstruct diffusion more than convection in tumors, which has significant implications for drug delivery in tumors and for tissue engineering applications.
Journal ArticleDOI
Vascular endothelial growth factors and vascular permeability.
TL;DR: A synthesis of existing data reveals that in intact vessels the co-ordination of the pathways is still not understood, and the mechanisms through which these are thought to interact to control permeability are dependent on the experimental system.
References
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Journal ArticleDOI
The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
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Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Susan K. Hobbs,Wayne L. Monsky,Fan Yuan,W. G. Roberts,Linda G. Griffith,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.
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The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
TL;DR: Findings show that flt encodes a receptor for VEGF-VPF, a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation.