Showing papers in "Regulatory Peptides in 1984"

TL;DR: Neuropeptide Y greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries.

TL;DR: Endocrine cells containing peptide YY (PYY) were numerous in the rectum, colon and ileum of rat, pig and man and few in the duodenum and jejunum of man.

TL;DR: The concentrations of the hormone were too great to be explained by known circulating levels of the polypeptides, and their presence in steroid secreting organs suggests a possible role for them in steroidogenesis.

TL;DR: In the present study of mouse, rat and pig, immunocytochemistry showed immunoreactive PHI to coexist completely with immunore Active NPY in non-adrenergic nerve fibres and nerve cell bodies, which was unexpected, since the VIP precursor does not contain NPY-like sequences.

TL;DR: Chromatographic analysis by means of reverse phase high pressure liquid chromatography shows that NPY immunoreactivity of human extracts elutes in an earlier position than the porcine standard, it seems likely therefore that human and porcines NPY differ in their amino acid sequences.

TL;DR: The results indicate that centrally administered neuropeptides produce reactions specific for each nerve, as shown in the case of VIP and TRH, respectively.

TL;DR: The ratio between the amounts of immunoreactivities in the two types of extracts varied considerably between tissues, indicating that tachykinin immunoreactive components may be present in different relative proportions in various tissues.

TL;DR: It is demonstrated that urinary EGF mainly originates from the kidneys and is localized to the renal juxtaglomerular apparatus.

TL;DR: The present results indicate that human and porcine 5 kDa GIP differ in chemical composition.

TL;DR: Mammalian atria contain peptides that have depressor and natriuretic activities and the HPLC profile of AP III suggested that smaller peptide fragments were formed after incubation with kidney homogenates, and the degradation of APIII was inhibited by bestatin, an aminopeptidase inhibitor, and SQ 20881, a carboxypeptid enzyme inhibitor.

TL;DR: It is concluded, that VIP is responsible for (at least part of) the neurally controlled fluid and bicarbonate secretion from the pig pancreas.

TL;DR: The results demonstrate that the infundibular nucleus plays a major role in control of GH secretion in man and that secretion of GRF appears late during fetal life; this suggests that the first stages of differentiation and development of GH producing cells in the human fetus do not depend on hypothalamic GRF secretion.

TL;DR: The VIP- and SP-containing nerve fibres reach the salivary glands by the parasympathetic nerves, and in both submaxillary and sublingual glands a certain fraction of VIP originates within the glands.

TL;DR: The increases in DNA synthesis and total DNA content after caerulein treatment support the trophic effect of this CCK analog on the pancreas and support the hypothesis that somatostatin may be considered an endogenous growth inhibitory factor for the Pancreas.

TL;DR: It is significant that peptides immunochemically related to FMRFamide and LPLRFamide occur in areas of rat brain concerned with autonomic control, and by intravenous and intracisternal routes.

TL;DR: It is indicated that CGRP acts within the central nervous system to potently decrease gastric acid secretion by mechanism(s) not dependent on intact sympathetic nervous function.

TL;DR: GRP appears to have an insulinotropic action in addition to a gastrin-releasing effect, which led to a significant elevation in serum insulin levels at 10 and 30 min, in comparison to controls.

TL;DR: Results indicate that while the changes in food and water intake produced by the central injection of cholecystokinin, bombesin or gastrin may involve central catecholamine systems, those occurring after its systemic administration do not.

TL;DR: It is concluded that secretin and VIP stimulate proximal duodenal bicarbonate secretion and are more potent than PHI.

TL;DR: A significant increase in food intake was obtained following proglumide injection, thus supporting the hypothesis that cholecystokinin, released by food in the duodenum, acts as a short-term satiety factor.

TL;DR: The enhanced potency and extended duration of action of RX 77368 over TRH, could make intracisternal injection of this peptide a useful test to induce centrally mediated vagal dependent stimulation of gastric secretion in rats.

TL;DR: The simultaneous measurement of increased plasma CCK levels and pancreatic secretion and the changes in the distribution of CCK peptides following amino acid infusion provides strong support that this assay detects physiologically relevant changes in biologically active CCK amino acid peptides.

TL;DR: The abundance of large molecular forms ofCCK in the circulating blood which are similar in potency to small forms, underlines their role in the physiology of CCK.

TL;DR: The C- terminal tetrapeptide appears to be the minimal C-terminal CCK sequence required for high affinity binding, and the observed differences in potencies are due to the receptor affinity and not sensitivity of the analog to degradation.

TL;DR: Using a porcine neuropeptide Y directed radioimmunoassay it was shown that acid extracts of human phaeochromocytoma tumour tissue contained a neuropePTide Y-like peptide.

TL;DR: The reduced contractile response in the 'denervated' anal segment is likely not due to a shortage of GRP fibres, and the idea that GRP is directly involved in intestinal motor functions did not support this view.

TL;DR: The locomotor effects of the peptides are discussed in relation to a possible dopamine-mediated mechanism which contrasts with the actions of TRH and the analogues on barbiturate anaesthesia.

TL;DR: Renin and epidermal growth factor are synthesized in large amounts by the male mouse submandibular glands in an exocrine manner and the pattern of increase in plasma is comparable to that in saliva though the substance concentration is lower.

TL;DR: Tachykinin immunoreactive material detected in tumor tissue and plasma of patients with carcinoid tumor may play a role in the symptomatology of the carcinoid syndrome.

TL;DR: There was a marked change in the ratios of CCK 8: CCK 33/39 down the intestine in human and porcine intestine, suggesting marked similarity of the CCKs in the two species, and may explain the changing patterns of CCks in circulation with time after ingestion of a fat meal.