Showing papers in "Transfusion in 2006"

TL;DR: Red cell transfusions are a potentially life‐saving therapy employed during the care of many critically ill patients to replace losses in hemoglobin to maintain oxygen delivery to vital organs and data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs.

TL;DR: This review will focus on the carbohydrate structures of VWF and recent studies suggesting that subtle variations in these structures (particularly differences in ABO blood group antigen expression) may have clinically significant effects on VWF proteolysis and clearance.

TL;DR: Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent hemostatic defects in cardiopulmonary bypass patients.

TL;DR: A prospective audit of all FFP transfusions at the Massachusetts General Hospital between September 2, 2004, and September 30, 2005, was performed to determine the effect of FFP on coagulation variables and correlation with bleeding in patients with mildly prolonged coagulated values.

TL;DR: Using the recent Consensus Panel recommendations, the incidence of transfusion-related acute lung injury (TRALI) and transfusion‐associated circulatory overload (TACO) in critically ill patients is described.

TL;DR: Civilian trauma centers and military combat support hospitals have evolved to treat increasingly severe injury and damage control surgery in which the restoration of normal anatomy is deferred to limit the progression of coagulopathy.

TL;DR: The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients.

TL;DR: This review focuses on red cell (RBC) vesiculation, a normal mechanism of development and subsequent adjustment to changing conditions, focusing on microvesicles shed by RBCs in vivo, and the possible role of these microparticles as diagnostic and investigative tools.

TL;DR: This research highlights the need to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers.

TL;DR: Effective methods for inactivating the SARS‐CoV in protein solutions are described in this report and may have the potential to contaminate donated blood and plasma‐derived products in the event of a future outbreak.

TL;DR: A unique and highly sensitive enzyme immunoassay (EIA) of ADAMTS13 activity is described and is described as a prerequisite for a differential diagnosis of thrombotic microangiopathies.

TL;DR: Alloimmunization after exposure to red cell (RBC) alloantigens depends on genetic and acquired patient‐related factors, dose and route of administration, and the immunogenicity of the antigen, but exact kinetics are still unknown.

TL;DR: It was hypothesized that PLT‐derived microvesicles interact with breast cancer cells, increasing their invasiveness.

TL;DR: Some blood donation–related adverse events (AEs) can negatively impact the blood donor return rate (BDRR) and decrease donor retention.

TL;DR: Bacterial screening of platelet concentrates by aerobic and anaerobic culturing (BacT/ALERT, bioMérieux) was introduced in the Netherlands in October 2001 and showed promising results.

TL;DR: The inflammatory status of a transfusion recipient would influence immunization to transfused RBCs was hypothesized to play an important role in rates of alloimmunization.

TL;DR: The objective of this study was to develop and validate an accurate and simple clinical index to stratify cardiac surgery patients according to their blood transfusion needs.

TL;DR: These studies evaluated the efficacy of PCT to inactivate pathogens in plasma and the effect of P CT on plasma function.

TL;DR: Removal of stored supernatant abrogates most transfusion reactions to leukoreduced platelets (PLTs), suggesting that PLT‐derived soluble mediators are involved.

TL;DR: Intravenous immune globulin has been approved for use in 6 conditions: immune thrombocytopenic purpura, pediatric HIV infection, Kawasaki disease, prevention of graft versus host disease (GVHD) and infection in bone marrow transplant recipients.

TL;DR: The accumulation of cytokines in PLT concentrates during storage is described to describe the processes of hemostasis and inflammation in blood platelets.

TL;DR: Because the probability of repeat transfusion increases with longer life expectancy, it was wondered to which extend non–chronically transfused alloimmunized patients are prone to form additional antibodies after repeat transfusions events.

TL;DR: The effectiveness of a restrictive transfusion trigger plus stimulation of erythropoiesis was evaluated, with or without blood salvage, for reducing ABT in TKR patients.

TL;DR: This data indicates that Buffy coats are becoming less available as a source of research‐grade peripheral blood mononuclear cells (PBMNCs) and alternative sources of these cells were investigated.

TL;DR: Evidence of hyperhemolysis is provided in this group of patients with sickle cell anemia who experience significant decrease in their hemoglobin level and significant increase in reticulocyte count during the progression of uncomplicated acute painful episodes.

TL;DR: There are no published clinical trialsthat have rigorously evaluated the relationship between anemia, transfusion, and functional recovery and two trialsevaluating transfusion thresholds are registered on the ClinicalTrials.gov website.

TL;DR: The aim of this work was to elucidate the mechanisms underlying relative immunogenicity, a characteristic of protein red blood cell (RBC) antigens, which has long been known but the mechanisms remain unclear.

TL;DR: Clinical experience indicates rFVIIa to be a safe treatment for currently approved indications within hemophilia and little information is available, however, for patient populations outside this clinical setting.

TL;DR: From the American Red Cross, Southeastern Michigan Region, Detroit, Michigan.

TL;DR: Platelet bacterial contamination is the most common transfusion‐associated infection in patients with PLT and it is important to understand the impact of interventions addressing this problem.