Journal ArticleDOI
12: IL-37 protects against obesity-induced inflammation and insulin resistance
Dov B. Ballak,Suzhao Li,Janna A. van Diepen,Alexander R. Moschen,H.J. Jansen,Anneke Hijmans,Gert-Jan Groenhof,Philip Bufler,Sander Kersten,Leo A. B. Joosten,Herbert Tilg,Charles A. Dinarello,Charles A. Dinarello,Mihai G. Netea,Cees J. Tack,Rinke Stienstra,Rinke Stienstra +16 more
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TLDR
It is reported that IL-37 exerts anti-inflammatory actions, which modulates obesity-induced inflammation and insulin resistance in mice and humans.About:
This article is published in Cytokine.The article was published on 2013-09-01. It has received 5 citations till now. The article focuses on the topics: Adipose tissue & White adipose tissue.read more
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Journal ArticleDOI
Suppression of inflammation and acquired immunity by IL-37
TL;DR: In humans, IL‐37 likely functions to limit excessive inflammation: accordingly,IL‐37 levels are abnormal in patients with inflammatory and autoimmune diseases and the potential for development of this cytokine as a therapeutic agent is discussed.
Journal ArticleDOI
IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity.
Liang Ye,Ling Ji,Zhongyang Wen,Yanfei Zhou,Dongsheng Hu,Yanqun Li,Ting Yu,Bingni Chen,Jinshun Zhang,Liping Ding,Jing Du,Zhong Huang +11 more
TL;DR: IL-37 is an important cytokine in the control of SLE pathogenesis by suppressing the production of inflammatory cytokines, and may provide a novel research target for the pathogenesis and therapy of Sle.
Journal ArticleDOI
Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity.
Bingni Chen,Kunzhao Huang,Liang Ye,Yanqun Li,Jiawei Zhang,Jinshun Zhang,Xinmin Fan,Xiaokai Liu,Li Li,Jinxia Sun,Jing Du,Zhong Huang +11 more
TL;DR: Interleukin-37 inhibits the expressions of the pro-inflammatory cytokines from PBMCs in AS patients, indicating the potential anti-inflammatory role of IL-37 in AS.
Journal ArticleDOI
Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells.
TL;DR: Increased level of IL-37 in patients with Graves' disease are associated with TNF-α, IL-6,IL-17 and disease activity, and it plays a protective role against inflammatory effect in GD by inhibiting the production of proinflammatory cytokines.
Journal ArticleDOI
Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR.
TL;DR: The functions of these IL-1 cytokine family members in the regulation of allergic airway inflammation and asthma as they have been assessed clinically, in vitro and in mouse models are reviewed.
Related Papers (5)
IL-37 protects against obesity-induced inflammation and insulin resistance
Dov B. Ballak,Janna A. van Diepen,Alexander R. Moschen,H.J. Jansen,Anneke Hijmans,Gert-Jan Groenhof,Floris Leenders,Philip Bufler,Mark V. Boekschoten,Michael Müller,Sander Kersten,Suzhao Li,Soohyun Kim,Hadar Eini,Eli C. Lewis,Leo A. B. Joosten,Herbert Tilg,Mihai G. Netea,Cees J. Tack,Charles A. Dinarello,Rinke Stienstra +20 more