Journal ArticleDOI
1H NMR-based metabolite profiling for biomarker identification.
TLDR
This review critically discusses recent findings of urine (non-invasive) and blood serum and plasma (minimally invasive) metabolomics, focusing on key role of metabolites and their use as potential biomarkers for diagnostic purposes.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-03-01. It has received 32 citations till now. The article focuses on the topics: Blood serum & Metabolome.read more
Citations
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Journal ArticleDOI
Quantitative NMR-Based Biomedical Metabolomics: Current Status and Applications.
Alexandra A. Crook,Robert Powers +1 more
TL;DR: The non-destructive nature of NMR-based metabolomics allows for multidimensional analysis of biomarkers that facilitates unambiguous assignment and quantification of metabolites in complex biofluids.
Journal ArticleDOI
Chromatography hyphenated to high resolution mass spectrometry in untargeted metabolomics for investigation of food (bio)markers
Leticia Lacalle-Bergeron,David Izquierdo-Sandoval,Juan V. Sancho,Francisco J. López,Félix Hernández,Tania Portolés +5 more
TL;DR: An overview of the most widely adopted strategies based on the use of high resolution mass spectrometry-based techniques for the identification of food (bio)markers through the untargeted metabolomics workflow is provided.
Journal ArticleDOI
Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment.
Julia Hernandez-Baixauli,Sergio Quesada-Vázquez,Roger Mariné-Casadó,Katherine Gil Cardoso,Antoni Caimari,Josep M. del Bas,Xavier Escoté,Laura Baselga-Escudero +7 more
TL;DR: This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis and proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for patients.
Journal ArticleDOI
Circadian and Sleep Metabolomics Across Species.
TL;DR: Human studies as well as key findings from metabolomics studies using mice, Drosophila, and zebrafish are summarized, showing a limitation in existing literature is a lack of interpretation regarding dynamic synthesis or catabolism within metabolite pools.
References
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Journal ArticleDOI
Thyroid Hormone Regulation of Metabolism
TL;DR: The role of TH in regulating metabolic pathways has led to several new therapeutic targets for metabolic disorders and understanding the mechanisms and interactions of the various TH signaling pathways in metabolism will improve the likelihood of identifying effective and selective targets.
Journal ArticleDOI
Beta cell dysfunction and insulin resistance.
TL;DR: Beta cell dysfunction supersedes insulin resistance in inducing diabetes and both pathological states influence each other and presumably synergistically exacerbate diabetes.
Journal ArticleDOI
Non-alcoholic fatty liver disease and diabetes
TL;DR: This review has summarised and critically evaluated the available data, with the aim of helping to inform the reader as to the most pertinent issues when managing patients with co-existent NAFLD and T2DM.
Journal ArticleDOI
Targeted Metabolomics for Biomarker Discovery
TL;DR: This Review highlights important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, aswell as targeted metabolomics by employing high-throughput mass spectrometry.
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Serum metabolomics as a novel diagnostic approach for disease: a systematic review.
Aihua Zhang,Hui Sun,Xijun Wang +2 more