Journal ArticleDOI
5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element
TLDR
These findings warrant further studies using animal models to develop a novel LDL-cholesterol lowering agent as a possible strategy to treat atherosclerosis-related cardiovascular diseases.About:
This article is published in Atherosclerosis.The article was published on 2013-01-01. It has received 32 citations till now. The article focuses on the topics: MRNA stabilization & AU-rich element.read more
Citations
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Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis
TL;DR: A working model of integrated cholesterol transport is proposed, termed the cholesterol transport system (CTS), to describe body cholesterol metabolism, which involves the classical view of RCT but also contains other steps, such as cholesterol absorption in the small intestine, low-density lipoprotein uptake by the liver, and transintestinal cholesterol excretion.
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Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)
TL;DR: The role HuR plays in the pathophysiology of different diseases and ongoing therapeutic strategies to target HuR will be reviewed, with a strong belief that targeting HuR could be a powerful therapeutic target to treat different diseases, particularly cancer, in the near future.
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IAVPGEVA, IAVPTGVA, and LPYP, three peptides from soy glycinin, modulate cholesterol metabolism in HepG2 cells through the activation of the LDLR-SREBP2 pathway
TL;DR: The experiments demonstrated that IAVPGEVA, IAVPTGVA, and LPYP are able to interfere with the catalytic activity of HMGCoAR and to modulate the cholesterol metabolism, through the activation of the LDLR-SREBP2 pathway, increasing the ability of HepG2 cells to uptake the LDL.
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The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation.
TL;DR: Signal-dependent phosphorylation of mRNA-binding proteins often alters their subcellular localization or RNA-binding affinity, which results in unstable mRNAs being stabilized, with their translational arrest being released and cytokine production being released.
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Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis.
TL;DR: In this article, the authors describe decades of research aimed at identifying key molecules and cellular players involved in each main aspect of hepatic cholesterol metabolism and summarize the recent advances regarding the biological processes of liver cholesterol transport and its role in NAFLD and atherosclerosis.
References
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Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators
TL;DR: A 33-nucleotide sequence, comprised entirely of A and T residues and located in the 3'-untranslated region, is conserved in toto in the murine and human TNF mRNAs.
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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
Wei-Jia Kong,Jing Wei,Parveen Abidi,Meihong Lin,Satoru Inaba,Cong Li,Yanling Wang,Zi-Zheng Wang,Shuyi Si,Huai-Ning Pan,Shukui Wang,Jingdan Wu,Yue Wang,Zhuorong Li,Jingwen Liu,Jian-Dong Jiang,Jian-Dong Jiang +16 more
TL;DR: Findings show berberine (BBR) as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.
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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
TL;DR: AICAR provides direct evidence that the inhibition by AMPK of activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase also operates in intact cells, and should be a useful tool for identifying new target pathways and processes regulated by theprotein kinase cascade.
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Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
TL;DR: The AMPK cascade is the probable target for the antidiabetic drug metformin, and current indications are that it is responsible for many of the beneficial effects of exercise in the treatment and prevention of type 2 diabetes and the metabolic syndrome.