Journal ArticleDOI
A 128 /spl times/ 128 CMOS bio-sensor array for extracellular recording of neural activity
B. Eversmann,Martin Jenkner,F. Hofmann,Christian Paulus,R. Brederlow,B. Holzapfl,Peter Fromherz,M. Merz,M. Brenner,M. Schreiter,R. Gabl,K. Plehnert,M. Steinhauser,Gerald Dr. Eckstein,Doris Schmitt-Landsiedel,Roland Thewes +15 more
- Vol. 38, Iss: 12, pp 2306-2317
TLDR
A CMOS sensor array for monitoring neural signals of living cells with 128 /spl times/ 128 pixels in a 1 mm/sup 2/ area is described, using a sensor-MOSFET mismatch-compensating current-mode technique.Abstract:
Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal-oxide-semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 /spl mu/m /spl times/ 7.8 /spl mu/m for imaging of neural activity. The related circuit and system issues as well as process aspects are discussed. A mismatch-canceling calibration circuitry with current mode signal representation is used. Results from first biological experiments are presented, which prove full functionality of the chip.read more
Citations
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Proceedings ArticleDOI
A 128 × 128 CMOS bio-sensor array for extracellular recording of neural activity
B. Eversmann,Martin Jenkner,Christian Paulus,F. Hofmann,R. Brederlow,B. Holzapfl,Peter Fromherz,M. Brenner,M. Schreiter,R. Gabl,K. Plehnert,M. Steinhauser,Gerald Dr. Eckstein,Doris Schmitt-Landsiedel,Roland Thewes +14 more
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