Journal ArticleDOI
A new fixed-array multi-microelectrode system designed for long-term monitoring of extracellular single unit neuronal activity in vitro.
TLDR
This two-dimensional system can be used as the floor of a tissue culture chamber and should be suitable for simultaneous long-term monitoring of single unit extracellular electrical activity from more than 30 neurons in culture.About:
This article is published in Neuroscience Letters.The article was published on 1977-11-01. It has received 299 citations till now. The article focuses on the topics: Microelectrode.read more
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Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms
TL;DR: It is suggested that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them.
Journal ArticleDOI
Diverse Applications of Nanomedicine
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,Frauke Alves,Frauke Alves,Anne M. Andrews,Sumaira Ashraf,Lajos P. Balogh,Laura Ballerini,Alessandra Bestetti,Cornelia Brendel,Susanna Bosi,Mónica Carril,Warren C. W. Chan,Chunying Chen,Xiaodong Chen,Xiaoyuan Chen,Zhen Cheng,Daxiang Cui,Jianzhong Du,Christian Dullin,Alberto Escudero,Alberto Escudero,Neus Feliu,Mingyuan Gao,Michael D. George,Yury Gogotsi,Arnold Grünweller,Zhongwei Gu,Naomi J. Halas,Norbert Hampp,Roland K. Hartmann,Mark C. Hersam,Patrick Hunziker,Ji Jian,Xingyu Jiang,Philipp Jungebluth,Pranav Kadhiresan,Kazunori Kataoka,Ali Khademhosseini,Jindřich Kopeček,Nicholas A. Kotov,Harald F. Krug,Dong Soo Lee,Claus-Michael Lehr,Kam W. Leong,Xing-Jie Liang,Mei Ling Lim,Luis M. Liz-Marzán,Xiaowei Ma,Paolo Macchiarini,Huan Meng,Helmuth Möhwald,Paul Mulvaney,Andre E. Nel,Shuming Nie,Peter Nordlander,Teruo Okano,Jose Oliveira,Tai Hyun Park,Reginald M. Penner,Maurizio Prato,Maurizio Prato,Víctor F. Puntes,Vincent M. Rotello,Amila Samarakoon,Raymond E. Schaak,Youqing Shen,Sebastian Sjöqvist,Andre G. Skirtach,Andre G. Skirtach,Mahmoud Soliman,Molly M. Stevens,Hsing-Wen Sung,Ben Zhong Tang,Rainer Tietze,Buddhisha Udugama,J. Scott VanEpps,Tanja Weil,Tanja Weil,Paul S. Weiss,Itamar Willner,Yuzhou Wu,Yuzhou Wu,Lily Yang,Zhao Yue,Qian Zhang,Qiang Zhang,Xian-En Zhang,Yuliang Zhao,Xin Zhou,Wolfgang J. Parak +91 more
TL;DR: An overview of recent developments in nanomedicine is provided and the current challenges and upcoming opportunities for the field are highlighted and translation to the clinic is highlighted.
Journal ArticleDOI
A neuron-silicon junction: a Retzius cell of the leech on an insulated-gate field-effect transistor.
TL;DR: An identified neuron of the leech, a Retzius cell, has been attached to the open gate of a p-channel field-effect transistor, and weak signals that resemble the first derivative of the action potential were observed.
Journal ArticleDOI
Revealing neuronal function through microelectrode array recordings
Marie Engelene J. Obien,Kosmas Deligkaris,Kosmas Deligkaris,Torsten Bullmann,Douglas J. Bakkum,Urs Frey,Urs Frey,Urs Frey +7 more
TL;DR: The ongoing advancements in microelectrode technology are introduced, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry.
Journal ArticleDOI
BioMEMS: state-of-the-art in detection, opportunities and prospects
TL;DR: The recent advances in this very exciting and important field are reviewed and a summary of the state of the art in the area of BioMEMS focusing on diagnostics, sensing, and detection is presented.
References
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A miniature microelectrode array to monitor the bioelectric activity of cultured cells
TL;DR: Electrical activity can be recorded extracellularly from contracting heart cells in vitro with the electrodes of 30-element microelectrode arrays built into the culture chambers with techniques developed by the microelectronics industry.
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A multielectrode perfusion chamber for tissue culture research
TL;DR: A chamber for neurophysiological investigations of nerve-tissue cultures, consisting essentially of a 12-electrode matrix made by spraying metal on a slide or coverslip, is described, because of the design of the chamber the location of the electrode in the culture can be verified visually at the same time.