Journal ArticleDOI
A comparison of different strategies for antimicrobial peptides incorporation onto/into lipid nanocapsules.
Nada Matougui,Anne-Claire Groo,Anita-Monika Umerska,Anita-Monika Umerska,Viviane Cassisa,Patrick Saulnier +5 more
TLDR
A lipid nanocapsule-based platform appears suitable to deliver AMPs, and the covalent attachment strategy turned out to be less conclusive due to peptide inactivation.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2019-07-01. It has received 17 citations till now. The article focuses on the topics: Antimicrobial peptides & Peptide.read more
Citations
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Journal ArticleDOI
Nanoformulation of Peptides for Pharmaceutical Applications: In Vitro and In Vivo Perspectives
Thimmiah Bhargavi Ram,Chien Chien Belinda Tang,Siaw Fui Kiew,Sie Yon Lau,G. Gobi,Jeevanandam Jaison,Michael K. Danquah +6 more
TL;DR: In this article , an overview of the peptide nano-formulation approaches as well as recent developments in the in vitro and in vivo analyses of nanoformulated peptides for pharmaceutical applications are discussed.
Journal ArticleDOI
Enhancing the stability, BBB permeability and neuroprotective activity of verbascoside in vitro using lipid nanocapsules in combination with menthol.
TL;DR: In this paper , verbascoside was encapsulated into lipid nanocapsules (LNC) by reverse micelle (RM) to increase its stability and neuroprotective activity.
References
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Journal ArticleDOI
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
TL;DR: An update on potentially effective antibacterial drugs in the late-stage development pipeline is provided, in the hope of encouraging collaboration between industry, academia, the National Institutes of Health, the Food and Drug Administration, and the Centers for Disease Control and Prevention work productively together.
Journal ArticleDOI
Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?
TL;DR: Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational resistance to cephalosporins less readily than Enterobacter species, and has less inherent resistance than Stenotrophomonas maltophilia.
Journal ArticleDOI
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
Journal ArticleDOI
LL-37, the only human member of the cathelicidin family of antimicrobial peptides.
TL;DR: LL-37, the only cathelicidin-derived antimicrobial peptide found in humans, is shown to exhibit a broad spectrum of antimicrobial activity and has been found to have additional defensive roles such as regulating the inflammatory response and chemo-attracting cells of the adaptive immune system to wound or infection sites.
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Peptidomimetics—Tailored Enzyme Inhibitors†
TL;DR: Rational design is advancing rapidly, and it is already clear that developments in the area of peptidomimetics have given a great boost to peptide chemistry as a whole, and this can be expected to continue, so that in future peptide Chemistry may be characterized by a type of symbiotic alliance between peptides and non-peptides.