Journal ArticleDOI
A comparison of different strategies for antimicrobial peptides incorporation onto/into lipid nanocapsules.
Nada Matougui,Anne-Claire Groo,Anita-Monika Umerska,Anita-Monika Umerska,Viviane Cassisa,Patrick Saulnier +5 more
TLDR
A lipid nanocapsule-based platform appears suitable to deliver AMPs, and the covalent attachment strategy turned out to be less conclusive due to peptide inactivation.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2019-07-01. It has received 17 citations till now. The article focuses on the topics: Antimicrobial peptides & Peptide.read more
Citations
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Aromatic and terpenic compounds loaded in lipidic nanocapsules: activity against multi-drug resisant Acinobacter baumannii assessed in vitro and in a murine model of sepsis
Angélique Montagu,Patrick Saulnier,Viviane Cassisa,Elisabeth Rossines,Matthieu Eveillard,Marie-Laure Joly-Guillou +5 more
TL;DR: It is the first time that antimicrobial essential oils can be administered intraperitonneally and an important antibacterial activity against A. baumannii is shown, similar to the activity of non-encapsulated mixtures.
Journal ArticleDOI
Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades.
Matheus Aparecido dos Santos Ramos,Luciani Gaspar de Toledo,Larissa Spósito,Gabriel Davi Marena,Laura Caminitti Lima,Giovanna Capaldi Fortunato,Victor Hugo Sousa Araujo,Taís Maria Bauab,Marlus Chorilli +8 more
TL;DR: A review of the scientific literature brings the applicability of nanotechnology-based lipid systems as an innovative tool in the improvement of bacterial infections treatment as mentioned in this paper, where important studies involving the use of liposomes, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, microemulsion and lipid nanocapsules were verified in the period from 2000 to 2020, where important scientific results were found and will serve as a basis for the use to remain in constant updating.
Journal ArticleDOI
Liposomes encapsulating novel antimicrobial peptide Omiganan: characterization and its pharmacodynamic evaluation in atopic dermatitis and psoriasis mice model.
TL;DR: The present study confirms that Omiganan liposomal formulation can be an effective, safe, and novel alternative treatment approach in atopic dermatitis and psoriasis.
Journal ArticleDOI
Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease Treatment.
Line Séguy,Léna Guyon,Manon Maurel,Pascal Verdié,Audrey Davis,Sophie Corvaisier,Vincent Lisowski,Patrick Dallemagne,Anne-Claire Groo,Aurélie Malzert-Fréon +9 more
TL;DR: In this paper, the potential therapeutic effects of tegaserod, an effective agent for irritable bowel syndrome, were assessed for Alzheimer's disease treatment, and the peptide-22 functionalized nanoemulsions were developed and functionalized by a blood-brain barrier shuttle peptide.
Journal ArticleDOI
Cathelicidins and defensins antimicrobial host defense peptides in the treatment of TB and HIV: Pharmacogenomic and nanomedicine approaches towards improved therapeutic outcomes
Prince N. Dlozi,Angelina V Gladchuk,Rustin D. Crutchley,N. Keuler,Renier Coetzee,Admire Dube +5 more
TL;DR: In this paper , the potential viability of using cathelicidins and defensins as novel pharmacotherapy in the management of TB and HIV, highlight potential pharmacogenomic implications in host mediated immunity and AMP therapeutic applications, as well as propose novel drug delivery strategies represented by nanomedicine for AMPs.
References
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Journal ArticleDOI
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
TL;DR: An update on potentially effective antibacterial drugs in the late-stage development pipeline is provided, in the hope of encouraging collaboration between industry, academia, the National Institutes of Health, the Food and Drug Administration, and the Centers for Disease Control and Prevention work productively together.
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Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?
TL;DR: Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational resistance to cephalosporins less readily than Enterobacter species, and has less inherent resistance than Stenotrophomonas maltophilia.
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Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
Journal ArticleDOI
LL-37, the only human member of the cathelicidin family of antimicrobial peptides.
TL;DR: LL-37, the only cathelicidin-derived antimicrobial peptide found in humans, is shown to exhibit a broad spectrum of antimicrobial activity and has been found to have additional defensive roles such as regulating the inflammatory response and chemo-attracting cells of the adaptive immune system to wound or infection sites.
Journal ArticleDOI
Peptidomimetics—Tailored Enzyme Inhibitors†
TL;DR: Rational design is advancing rapidly, and it is already clear that developments in the area of peptidomimetics have given a great boost to peptide chemistry as a whole, and this can be expected to continue, so that in future peptide Chemistry may be characterized by a type of symbiotic alliance between peptides and non-peptides.