Journal ArticleDOI
A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis
Joan M. Bathon,Richard J. Martin,Roy Fleischmann,John Tesser,Michael Schiff,Edward C. Keystone,Mark C. Genovese,Mary Chester M. Wasko,Larry W. Moreland,Arthur L. Weaver,Joseph A. Markenson,Barbara K. Finck +11 more
TLDR
Subcutaneous [corrected] etanercept acted more rapidly to decrease symptoms and slow joint damage in patients with early active rheumatoid arthritis.Abstract:
Background Etanercept, which blocks the action of tumor necrosis factor, reduces disease activity in patients with long-standing rheumatoid arthritis. Its efficacy in reducing disease activity and preventing joint damage in patients with active early rheumatoid arthritis is unknown. Methods We treated 632 patients with early rheumatoid arthritis with either twice-weekly subcutaneous etanercept (10 or 25 mg) or weekly oral methotrexate (mean, 19 mg per week) for 12 months. Clinical response was defined as the percent improvement in disease activity according to the criteria of the American College of Rheumatology. Bone erosion and joint-space narrowing were measured radiographically and scored with use of the Sharp scale. On this scale, an increase of 1 point represents one new erosion or minimal narrowing. Results As compared with patients who received methotrexate, patients who received the 25-mg dose of etanercept had a more rapid rate of improvement, with significantly more patients having 20 percent, ...read more
Citations
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Journal ArticleDOI
How to predict prognosis in early rheumatoid arthritis
TL;DR: This review attempts to answer the question of how to predict outcome in early RA by reporting the most reliable prognostic factors and some predictive models proposed for classification into benign, mild and severe RA.
Journal ArticleDOI
Full dose, reduced dose or discontinuation of etanercept in rheumatoid arthritis
Ronald F van Vollenhoven,Mikkel Østergaard,Marjatta Leirisalo-Repo,Till Uhlig,Marita Jansson,Esbjörn Larsson,Fiona Brock,Karin Franck-Larsson +7 more
TL;DR: Reduced dose ETN was also more effective than PBO in maintaining a favourable response, suggesting that a maintenance strategy with reduced doses ETN may be possible in a number of patients with established RA.
Journal ArticleDOI
Patient preferences and satisfaction in the treatment of rheumatoid arthritis with biologic therapy.
TL;DR: A review of the current literature on patient satisfaction, adherence, and preference for biologic therapy in RA finds that patient preferences for mode and frequency of administration, and for certain risks vs benefits as well as medication beliefs are central to uptake and adherence to these medications.
Journal ArticleDOI
Anti-tumor necrosis factor therapies.
TL;DR: For patients with established and early RA, anti-TNF therapies set a new standard for symptom control and joint protection.
Journal ArticleDOI
The role of interleukin-1 in bone resorption in rheumatoid arthritis
Vibeke Strand,A F Kavanaugh +1 more
TL;DR: In patients with active RA, treatment with the TNF blockers etanercept and infliximab, as well as with anakinra, a recombinant human IL-1 receptor antagonist, significantly reduced erosions and joint space narrowing, it remains to be determined whether slowing radiographic progression with these biological therapies will significantly improve long-term outcomes in RA.
References
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American college of rheumatology preliminary definition of improvement in rheumatoid arthritis
David T. Felson,David T. Felson,Jennifer J. Anderson,Jennifer J. Anderson,Maarten Boers,Claire Bombardier,Claire Bombardier,Daniel E. Furst,Daniel E. Furst,Charles H. Goldsmith,Charles H. Goldsmith,Linda M. Katz,Linda M. Katz,Robert W. Lightfoot,Robert W. Lightfoot,Harold E. Paulus,Harold E. Paulus,Vibeke Strand,Vibeke Strand,Peter Tugwell,Peter Tugwell,Michael E. Weinblatt,Michael E. Weinblatt,H. James Williams,H. James Williams,Frederick Wolfe,Stephanie Kieszak +26 more
TL;DR: The results suggest that the definition of improvement presented is statistically powerful and does not identify a large percentage of placebo-treated patients as being improved, which the authors hope will be used widely in RA trials.
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A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.
Michael E. Weinblatt,Joel M. Kremer,Arthur D. Bankhurst,Ken J. Bulpitt,Roy Fleischmann,Robert I. Fox,Christopher G. Jackson,Mary Lange,Daniel Burge +8 more
TL;DR: In patients with persistently active rheumatoid arthritis, the combination of etanercept and methotrexate was safe and well tolerated and provided significantly greater clinical benefit than metotrexate alone.
Journal ArticleDOI
Cancer statistics, 1997
Journal ArticleDOI
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein.
Larry W. Moreland,Scott Baumgartner,Michael Schiff,Elizabeth A. Tindall,Roy Fleischmann,Arthur L. Weaver,Robert E. Ettlinger,Stanley Cohen,William J. Koopman,Kendall Mohler,Michael B. Widmer,Consuelo M. Blosch +11 more
TL;DR: In this three-month trial TNFR:Fc was safe, well tolerated, and associated with improvement in the inflammatory symptoms of rheumatoid arthritis.
Journal ArticleDOI
Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial
Larry W. Moreland,Michael Schiff,Scott Baumgartner,Elizabeth A. Tindall,Roy Fleischmann,Ken J. Bulpitt,Arthur L. Weaver,Edward C. Keystone,Daniel E. Furst,Philip J. Mease,Eric Ruderman,David A. Horwitz,Daniel G. Arkfeld,Leslie Garrison,Daniel Burge,Consuelo M. Blosch,Mary Lange,Neil D. McDonnell,Michael E. Weinblatt +18 more
TL;DR: In a phase II study, etanercept (recombinant human tumor necrosis factor receptor [p75]:Fc fusion protein) safely produced rapid, dose-dependent improvement in rheumatoid arthritis over 3 months as discussed by the authors.