Journal ArticleDOI
A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels.
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TLDR
In this article, the authors evaluate the available evidence about the various channels potentially involved in Ca2+ leakage and draw conclusions about their relative importance, despite over 20 different proteins have been proposed to contribute to it.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2021-03-30. It has received 32 citations till now. The article focuses on the topics: SERCA & Unfolded protein response.read more
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Journal ArticleDOI
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter.
Amanda Kowalczyk,Amanda Kowalczyk,Omotola Gbadamosi,Kathryn Kolor,Jahree Sosa,Livia Andrzejczuk,Gregory A. Gibson,Claudette M. St. Croix,Maria Chikina,Elias Aizenman,Nathan L. Clark,Kirill Kiselyov +11 more
TL;DR: In this article, a case for identifying a transporter localization using evolutionary rate covariation (ERC) was presented, based on pairwise correlations of amino acid sequence evolutionary rates across the mammalian phylogeny.
Posted ContentDOI
Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter.
Amanda Kowalczyk,Amanda Kowalczyk,Omotola Gbadamosi,Kathryn Kolor,Jahree Sosa,Claudette M. St. Croix,Gregory A. Gibson,Maria Chikina,Elias Aizenman,Nathan L. Clark,Kirill Kiselyov +10 more
TL;DR: In this paper, a case for identifying a transporter localization using evolutionary rate covariation (ERC) was presented, based on pairwise correlations of amino acid sequence evolutionary rates across the mammalian phylogeny.
Journal ArticleDOI
Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing
Siarhei A. Dabravolski,Nikolay K. Sadykhov,Andrey G. Kartuesov,E. Borisov,Vasily N. Sukhorukov,Alexander N. Orekhov +5 more
TL;DR: The recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury are summarized.
Journal ArticleDOI
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+ signaling
TL;DR: Mutations in WFS1 and CISD2 (which encodes CDGSH iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts with juvenile diabetes.
Journal ArticleDOI
Ca2+ regulation of constitutive vesicle trafficking
John Sargeant,Jesse C. Hay +1 more
TL;DR: It is concluded that Ca2+ regulates an expanding series of distinct mechanistic steps, which together regulate the flux of cargo in response to genetic alterations as well as baseline and agonist-dependent Ca2-dependent signals.
References
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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
Steven O. Marx,Steven Reiken,Yuji Hisamatsu,Thotalla Jayaraman,Daniel Burkhoff,Nora Rosemblit,Andrew R. Marks +6 more
TL;DR: It is shown that protein kinase A (PKA) phosphorylation of RyR2 dissociates FKBP12.6 and regulates the channel open probability (Po), resulting in defective channel function due to increased sensitivity to Ca2+-induced activation.
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BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis
Luca Scorrano,Scott A. Oakes,Joseph T. Opferman,Emily H. Cheng,Mia D. Sorcinelli,Tullio Pozzan,Stanley J. Korsmeyer +6 more
TL;DR: BAX and BAK operate in both the ER and mitochondria as an essential gateway for selected apoptotic signals, and targeting of BAX to mitochondria selectively restored apoptosis to “BH3-only” signals.
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Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria
TL;DR: It is concluded that in vivo, domains of high [Ca2+]i are transiently generated close to IP3-gated channels and sensed by nearby mitochondria; this may provide an efficient mechanism for optimizing mitochondrial activity upon cell stimulation.
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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
TL;DR: The development of both positive and negative small-molecule modulators of apoptosis is now enabling researchers to translate the discoveries that have been made in the laboratory into clinical practice to positively impact human health.
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Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
TL;DR: Destabilization of calcium signalling seems to be central to the pathogenesis of Alzheimer's disease, and targeting this process might be therapeutically beneficial.