Journal ArticleDOI
A comprehensive review on the biological interest of quinoline and its derivatives.
TLDR
A review of quinoline-based marketed drugs can be found in this paper, where the authors provide information about the biological activities of these drugs, such as antibacterial, antifungal, antimycobacterial, antiviral, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2021-02-15. It has received 161 citations till now. The article focuses on the topics: Quinoline.read more
Citations
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Therapeutic potential of pyrrole and pyrrolidine analogs: an update
TL;DR: The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance as mentioned in this paper .
Journal ArticleDOI
Optimization for synthesized quinoline-based Cr3+, VO2+, Zn2+ and Pd2+complexes: DNA interaction, biological assay and in-silico treatments for verification
Hessah A. AL-Abdulkarim,Rafat M. El-Khatib,Faizah S. Aljohani,Asmaa Mahran,Arwa Alharbi,Gaber A.M. Mersal,Nashwa M. El-Metwaly,Nashwa M. El-Metwaly,Ahmed M. Abu-Dief,Ahmed M. Abu-Dief +9 more
TL;DR: In this article, a novel momonuclear metal chelates were derived from Zn(II), Pd(II, VO(II) and Cr(III) ions with azomethine (BSQ) [BSQ = 4-Bromo-2-(quinolin-8-yliminomethyl)-phenol] ligand.
Journal ArticleDOI
An insight into the advanced synthetic recipes to access ubiquitous indole heterocycles
Basavarajaiah Suliphuldevara Mathada,Nagesh Gunavanthrao Yernale,Jeelan N. Basha,Jaishree Badiger +3 more
TL;DR: In this article, a comprehensive exposure to assess indole heterocycles by conventional methods and also ingraining special advanced techniques is presented, to the best of our acquaintance, a comprehensive evaluation of these compounds is provided.
Journal ArticleDOI
Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review
TL;DR: In this paper , the authors present the recent advances in chemistry, medicinal potential and pharmacological applications of quinoline motifs to unveil their substantial efficacies for future drug development.
Journal ArticleDOI
Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift.
TL;DR: The borane-catalyzed synthesis of dihydroquinoline-4-ones is described in this paper, where amino-substituted chalcones undergo a 1,7-hydride shift upon Lewis acid activation to form a zwitterionic iminium enolate.
References
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Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
Kwak Eunice L,Raffaella Sordella,Daphne W. Bell,Godin-Heymann Nadia G,Ross A. Okimoto,Brian W. Brannigan,Patricia L. Harris,David R. Driscoll,Panos Fidias,Thomas J. Lynch,Sridhar K. Rabindran,John P. McGinnis,Allan Wissner,Sreenath V. Sharma,Kurt J. Isselbacher,Jeffrey Settleman,Daniel A. Haber +16 more
TL;DR: These findings suggest that one of these, HKI-272, may prove highly effective in the treatment of EGFR-mutant NSCLCs, including tumors that have become resistant to gefitinib or erlotinib.
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A Systematic Review on the Efficacy and Safety of Chloroquine for the Treatment of COVID-19
TL;DR: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19.
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TTD: Therapeutic Target Database
TL;DR: The Therapeutic Target Database (TTD) is designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets.
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A review on anticancer potential of bioactive heterocycle quinoline.
TL;DR: This review has compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of theQuinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.