Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
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TLDR
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.Abstract:
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.read more
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Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
TL;DR: Results suggest that DHH/PTCH1 signaling triggers Leydig cell differentiation by up-regulating Steroidogenic Factor 1 and P450 Side Chain Cleavage enzyme expression in Ptch1-expressing precursor cells located outside testis cords.
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Aromatase enzyme activity and sex determination in chickens
Alex Elbrecht,Roy G. Smith +1 more
TL;DR: This work has identified aromatase as a key developmental switch in the sex determination of chickens that causes genetic females to develop a permanent male phenotype.
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Sox proteins: regulators of cell fate specification and differentiation
Yusuke Kamachi,Hisato Kondoh +1 more
TL;DR: This Primer provides a mechanistic overview of how Sox family proteins function, as a paradigm for transcriptional regulation of development involving multi-transcription factor complexes, and discusses how Sox factors can thus regulate diverse processes during development.
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Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4
Marco W. Schilham,Mariëtte A. Oosterwegel,Petra Moerer,Jing Ya,P. A. J. De Boer,M. Van De Wetering,Sjef Verbeek,W. H. Lamers,Ada M. Kruisbeek,Ana Cumano,Hans Clevers +10 more
TL;DR: Using targeted genedisruption, it is found that Sox-4−/− embryos succumb to circulatory failure at day E14, a result of impaired development of the endocardial ridges into the semilunar valves and the outlet portion of the muscular ventricular septum.
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Expression of the mouse anti-müllerian hormone gene suggests a role in both male and female sexual differentiation.
TL;DR: The pattern of AMH expression in both sexes is correlated with cellular events occurring in gonadal development and some implications that this may have for its function and regulation are discussed.
References
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A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
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