Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
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TLDR
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.Abstract:
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.read more
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Journal ArticleDOI
Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin
TL;DR: Analytical analysis of a transgenic line that carries a mouse Hprt minigene on the Y chromosome indicated that the transgene-carrying Y is prone to non-disjunction, generating cells with two (or more) or no Y chromosomes in equal proportion.
Book ChapterDOI
Gene and enhancer trapping: mutagenic strategies for developmental studies.
David P. Hill,Wolfgang Wurst +1 more
TL;DR: This chapter discusses the merits and drawbacks of the use of mutagenic strategies in mouse that have been used in developmental systems, and one strategy that appears to be particularly promising in mammals, the enhancer or promoter trap, has been borrowed from “lower” systems.
Journal ArticleDOI
Both nuclear and cytoplasmic components are defective in oocytes of the B6.YTIR sex-reversed female mouse.
TL;DR: The results suggest that both nuclear and cytoplasmic components are defective in oocytes from XY females, suggesting that the primary cause of infertility can be attributed to oocytes rather than their surrounding somatic cells in the XY ovary.
Journal ArticleDOI
Evolution of the Male-Determining Gene SRY Within the Cat Family Felidae
V. King,P. N. Goodfellow,A. J. Pearks Wilkerson,Warren E. Johnson,Stephen J. O'Brien,Jill Pecon-Slattery +5 more
TL;DR: Comparative genomic analyses of SRY along with the adjacent noncoding 5′ flank and 3′ flank in 36 species of the cat family Felidae indicate that the nonc coding genomic flanks and SRY closely track species divergence, however, several inconsistencies are observed in SRY.
Journal ArticleDOI
Cloning and expression of Xenopus laevis xSox12 cDNA
TL;DR: The ovary was the most prominent in the expression of the Sox mRNA among the various tissues of adult frog as far as examined, and the size was determined to be 3.0 knt by Northern analysis.
References
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
Journal ArticleDOI
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
Journal ArticleDOI
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Journal ArticleDOI