Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
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TLDR
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.Abstract:
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.read more
Citations
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Role of platelet-derived growth factors in the testis.
TL;DR: A framework of the current knowledge is provided to clarify the useful information regarding how PDGFs function in individual cells of the testis.
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Genetics of sexual development: a new paradigm.
TL;DR: The classical paradigm of human and mammalian sexual development, largely based on work of Alfred Jost, depicts the genetic factor that determine(s) sex as influencing only the fate of the gonad, and a new paradigm is proposed to accommodate recent findings.
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Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development.
Simon P. Windley,Dagmar Wilhelm +1 more
TL;DR: The mechanisms of signal transduction within these pathways and the importance of these pathways throughout mammalian gonad development are reviewed, mainly concentrating on data obtained in mouse but including other species where appropriate.
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Characterization and mapping of the human SOX4 gene.
Christine J. Farr,David J. Easty,Jiannis Ragoussis,Jérôme Collignon,Robin Lovell-Badge,Peter N. Goodfellow +5 more
TL;DR: The SOX genes comprise a large family related by homology to the HMG-box region of the testis-determining gene SRY and there is no evidence for clustering of other members of the SOX1,-2, and-3 or SOX4 gene families around the SoX4 locus.
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Rainbow trout sox9 : cdna cloning, gene structure and expression
Nobuhiko Takamatsu,Hiromi Kanda,Michihiko Ito,Atsushi Yamashita,Shinya Yamashita,Tadayoshi Shiba +5 more
TL;DR: The rainbow trout and human SOX9 genes show a similar gene structure, and the two introns in the coding region are located at conserved positions.
References
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
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