Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
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A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.Abstract:
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.read more
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Journal ArticleDOI
Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.
Yasuhiro Yamauchi,Jonathan M. Riel,Victor A. Ruthig,Eglė A. Ortega,Michael J. Mitchell,Monika A. Ward +5 more
TL;DR: In mice, successful assisted reproduction can be achieved when the Y gene contribution is limited to only two genes, Sry and spermatogonial proliferation factor Eif2s3y, and these findings support the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
Book ChapterDOI
Genetic Influences on Sexual Behavior Differentiation
TL;DR: The data demonstrate that the development of sexual behaviors can be independent of genetic sex, and the genotype does play an important role in normal sexual differentiation.
Journal ArticleDOI
Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa
Chuya Shinzato,Chuya Shinzato,Akira Iguchi,Akira Iguchi,David C. Hayward,Ulrich Technau,Eldon E. Ball,David J. Miller +7 more
TL;DR: Differences in expression patterns between Acropora and Nematostella largely reflect fundamental differences in developmental processes, underscoring the diversity of mechanisms within the anthozoan Sub-Class Hexacorallia (Zoantharia).
Journal ArticleDOI
Binding of A/T-rich DNA by three high mobility group-like domains in c-Abl tyrosine kinase.
Yong-Jie Miao,Jean Y. J. Wang +1 more
TL;DR: Observations define a new class of DNA binding domains, the HLBs, which do not bind DNA with a high degree of sequence specificity, but may selectively bind to bent DNA or to sequences that are easier to distort.
Book ChapterDOI
Gametogenesis: A journey from inception to conception.
Hailey Larose,Adrienne Niederriter Shami,Haley Abbott,Gabriel L. Manske,Lei Lei,Saher Sue Hammoud +5 more
TL;DR: This chapter focuses on critical male and female genetic and epigenetic processes underlying normal gamete formation through their differentiation to fertilization and explores how knowledge gained has contributed to progress in areas with great clinical promise, such as in vitro gametogenesis.
References
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
Journal ArticleDOI
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
Journal ArticleDOI
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Journal ArticleDOI