Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
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TLDR
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.Abstract:
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.read more
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Turnover of Sex Chromosomes in the Stickleback Fishes (Gasterosteidae)
Joseph A. Ross,Joseph A. Ross,James R. Urton,James R. Urton,Jessica Boland,Michael D. Shapiro,Catherine L. Peichel +6 more
TL;DR: The sex-chromosome diversity that is uncovered in sticklebacks provides a rich comparative resource for understanding the mechanisms that underlie the rapid turnover of sex- Chromosome systems.
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Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal
TL;DR: The number of de novo mutations in SRY is now doubled to four, adding further strength to the argument that SRY, the sex-determining region Y gene, is TDF.
Journal ArticleDOI
Identification of SOX3 as an XX male sex reversal gene in mice and humans
Edwina Sutton,James N. Hughes,Stefan J. White,Ryohei Sekido,Jacqueline Tan,Valerie A. Arboleda,Nicholas Rogers,Kevin Christopher Knower,L. Rowley,Helen J. Eyre,Karine Rizzoti,Dale McAninch,João Gonçalves,Jennie Slee,Erin Turbitt,D L Bruno,Henrik Bengtsson,Vincent R. Harley,Eric Vilain,Andrew H. Sinclair,Robin Lovell-Badge,Paul Q. Thomas +21 more
TL;DR: SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad.
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SOX2 functions in adult neural stem cells
TL;DR: A new genetic model addresses the role of SOX2 in the adult brain and provides evidence that it is involved in the maintenance of neurons in specific regions, in the proliferation and/or maintenance of neural stem cells, and in neurogenesis.
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Dynamic expression of chicken sox2 and sox3 genes in ectoderm induced to form neural tissue
Maria Rex,Alex Orme,Dafe Uwanogho,Kevin Tointon,Peter Wigmore,Paul T. Sharpe,Paul J. Scotting +6 more
TL;DR: It is shown that cSox3 is expressed throughout the ectoderm that is competent to form nervous tissue before neural induction, which represents one of the earliest molecular responses to neural induction documented thus far.
References
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
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