Journal ArticleDOI
A meta-analysis of previous fracture and subsequent fracture risk
John A. Kanis,Olof Johnell,C De Laet,Helena Johansson,Anders Odén,Pierre D. Delmas,John A. Eisman,Saeko Fujiwara,P. Garnero,Heikki Kröger,Eugene V. McCloskey,Dan Mellström,Lee J. Melton,Huib A.P. Pols,J. Reeve,Alan J. Silman,Alan Tenenhouse +16 more
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TLDR
It is concluded that previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by measurement of BMD.About:
This article is published in Bone.The article was published on 2004-08-01. It has received 1159 citations till now. The article focuses on the topics: Hip fracture & Risk factor.read more
Citations
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Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Philip W. Kantoff,Celestia S. Higano,N. Shore,E. Roy Berger,Eric J. Small,David F. Penson,Charles H. Redfern,Anna C. Ferrari,Robert Dreicer,Robert B. Sims,Yi Xu,Mark W. Frohlich,Paul F. Schellhammer +12 more
TL;DR: The use of sipuleucel-T prolonged overall survival among men with metastatic castration-resistant prostate cancer and immune responses to the immunizing antigen were observed in patients who received sipuleUcel- T.
Journal ArticleDOI
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
John A. Kanis,Eugene V. McCloskey,Helena Johansson,Cyrus Cooper,René Rizzoli,Jean-Yves Reginster +5 more
TL;DR: In this paper, the European Foundation for Osteoporosis and Bone disease (subsequently the International osteopo- rosis Foundation) published guidelines for the diagnosis and management of osteoporrosis in a European setting.
Journal ArticleDOI
FRAX™ and the assessment of fracture probability in men and women from the UK
TL;DR: The models provide a framework which enhances the assessment of fracture risk in both men and women by the integration of clinical risk factors alone and/or in combination with BMD.
Journal ArticleDOI
Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA).
E Hernlund,Axel Svedbom,M Ivergard,Juliet E. Compston,Cyrus Cooper,Cyrus Cooper,J Stenmark,Eugene V. McCloskey,Bengt Jönsson,John A. Kanis +9 more
TL;DR: In spite of the high social and economic cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by the aging populations, the use of pharmacological interventions to prevent fractures has decreased in recent years, suggesting that a change in healthcare policy is warranted.
Journal ArticleDOI
2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary
Alexandra Papaioannou,Suzanne N Morin,Angela M. Cheung,Stephanie A. Atkinson,Jacques P. Brown,Sidney Feldman,David A. Hanley,Anthony B. Hodsman,Sophie A. Jamal,Stephanie M. Kaiser,Brent Kvern,Kerry Siminoski,William D. Leslie +12 more
TL;DR: There has been a paradigm shift in the prevention and treatment of osteoporosis and fractures, and the focus now is on preventing fragility fractures and their negative effects.
References
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Journal ArticleDOI
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
Dennis M. Black,Steven R. Cummings,David B. Karpf,Jane A. Cauley,Desmond E. Thompson,Michael C. Nevitt,Douglas C. Bauer,Harry K. Genant,William L. Haskell,Robert Marcus,Susan M. Ott,James C. Torner,Sara A. Quandt,Theodore F. Reiss,Kristine E. Ensrud +14 more
TL;DR: Among women with low bone mass and existing vertebral fractures, alendronate is well tolerated and substantially reduces the frequency of morphometric and clinical vertebra fractures, as well as other clinical fractures.
Journal ArticleDOI
Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group.
Steven R. Cummings,Michael C. Nevitt,Warren S. Browner,Katie L. Stone,Kathleen M. Fox,Kristine E. Ensrud,Jane A. Cauley,Dennis Black,Thomas M. Vogt +8 more
TL;DR: Women with multiple risk factors and low bone density have an especially high risk of hip fracture and maintaining body weight, walking for exercise, avoiding long-acting benzodiazepines, minimizing caffeine intake, and treating impaired visual function are among the steps that may decrease the risk.
Journal ArticleDOI
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
TL;DR: Measurements of bone mineral density can predict fracture risk but cannot identify individuals who will have a fracture, and a programme of screening menopausal women for osteoporosis by measuring bone density cannot be recommended.
Journal ArticleDOI
Epidemiology and outcomes of osteoporotic fractures.
TL;DR: In this paper, epidemiological research was done and used to identify individuals at high risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need, which could potentially be as expensive as medical treatment of fractures.
Journal ArticleDOI
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial.
Steven R. Cummings,Dennis M. Black,Desmond E. Thompson,William B. Applegate,Elizabeth Barrett-Connor,Thomas Musliner,Lisa Palermo,Ronald J. Prineas,Susan M. Rubin,Jean Scott,Thomas M. Vogt,Robert B. Wallace,A. John Yates,Andrea Z. LaCroix +13 more
TL;DR: In women with low BMD but without vertebral fractures, 4 years of alendronate safely increased BMD and decreased the risk of first vertebral deformity.