Journal ArticleDOI
A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles.
TLDR
The LSPR nanobiosensor provides a pathway to ultrasensitive biodetection experiments with extremely simple, small, light, robust, low-cost instrumentation that will greatly facilitate field-portable environmental or point-of-service medical diagnostic applications.Abstract:
Triangular silver nanoparticles (∼100 nm wide and 50 nm high) have remarkable optical properties. In particular, the peak extinction wavelength, λmax of their localized surface plasmon resonance (LSPR) spectrum is unexpectedly sensitive to nanoparticle size, shape, and local (∼10−30 nm) external dielectric environment. This sensitivity of the LSPR λmax to the nanoenvironment has allowed us to develop a new class of nanoscale affinity biosensors. The essential characteristics and operational principles of these LSPR nanobiosensors will be illustrated using the well-studied biotin−streptavidin system. Exposure of biotin-functionalized Ag nanotriangles to 100 nM streptavidin (SA) caused a 27.0 nm red-shift in the LSPR λmax. The LSPR λmax shift, ΔR/ΔRmax, versus [SA] response curve was measured over the concentration range 10-15 M < [SA] < 10-6 M. Comparison of the data with the theoretical normalized response expected for 1:1 binding of a ligand to a multivalent receptor with different sites but invariant af...read more
Citations
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Journal ArticleDOI
Self-assembled monolayers of thiolates on metals as a form of nanotechnology.
Journal ArticleDOI
Localized Surface Plasmon Resonance Spectroscopy and Sensing
TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
Journal ArticleDOI
Nanostructures in Biodiagnostics
Nathaniel L. Rosi,Chad A. Mirkin +1 more
TL;DR: Nathaniel L. Rosi focuses on the rational assembly of DNA-modified nanostructures into larger-scale materials and their roles in biodiagnostic screening for nucleic acids.
Journal ArticleDOI
Gold nanoparticles in chemical and biological sensing.
TL;DR: The advent of AuNP as a sensory element provided a broad spectrum of innovative approaches for the detection of metal ions, small molecules, proteins, nucleic acids, malignant cells, etc. in a rapid and efficient manner.
Book
Principles of nano-optics
Lukas Novotny,Bert Hecht +1 more
TL;DR: In this paper, the authors proposed a method for propagating and focusing of optical fields in a nano-optics environment using near-field optical probes and probe-sample distance control.
References
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Journal ArticleDOI
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TL;DR: When coupled with a signal amplification method based on nanoparticle-promoted reduction of silver(I), the sensitivity of this scanometric array detection system exceeds that of the analogous fluorophore system by two orders of magnitude.
Journal ArticleDOI
Nanosphere Lithography: A Versatile Nanofabrication Tool for Studies of Size-Dependent Nanoparticle Optics
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