Journal ArticleDOI
A new approach to the synthesis of benzofuro[3,2-b]quinolines, benzothieno[3,2-b]quinolines and indolo[3,2-b]quinolines†
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TLDR
In this article, a new method for preparation of quindoline 2 and its O and S analogs was presented, which represents a new way of preparation of the quinoline.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2000-07-01. It has received 32 citations till now. The article focuses on the topics: Benzofuran & Benzothiophene.read more
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Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.
Jin Lin Zhou,Yu Jing Lu,Tian Miao Ou,Junmin Zhou,Zhi Shu Huang,Xiao Feng Zhu,Cui Juan Du,Xian Zhang Bu,Lin Ma,Lian Quan Gu,Li Yueming,Li Yueming,Albert S. C. Chan,Albert S. C. Chan +13 more
TL;DR: The results revealed that the introduction of electron-donating groups such as substituted amino groups at the C-11 position of quindoline significantly improved the inhibitory effect on telomerase activity.
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Indoloquinolines as Scaffolds for Drug Discovery
TL;DR: An overview of the potential of indoloquinolines as scaffolds in drug discovery is presented by reviewing the in vitro and in vivo biological activities of natural and synthetic analogues, as well as the proposed mechanisms of action and structure-activity relationships.
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Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine
TL;DR: This review describes the isolation, brief biological activities and various synthetic methodologies developed during recent years for the preparation of this important class of alkaloids, with special emphasis on preparation and properties of cryptolepine 1, isocryptolepine 2 and neocryptolespine 3.
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Substituted indoloquinolines as new antifungal agents.
TL;DR: Comparison of MICs of a number of 2-substituted indoloquinolines designed to increase potency and expand the antifungal spectrum of cryptolepine shows them to be comparable to Amphotericin B and Ketoconazole.
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Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.
Prakash Jagtap,Erkan Baloglu,Garry Southan,William Williams,Aloka Roy,Alexander Nivorozhkin,Nelson Landrau,Kevin Desisto,and Andrew L. Salzman,Csaba Szabó +9 more
TL;DR: The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2 -c]isalquinolinones are described.
References
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In Vitro and in Vivo Antiplasmodial Activity of Cryptolepine and Related Alkaloids from Cryptolepis sanguinolenta
TL;DR: Three different extracts and four alkaloids from the root bark of Cryptolepis sanguinolenta have been assessed in vitro against Plasmodium falciparum D-6, K-1, and W-2 (chloroquine-resistant strains) and showed a strong antiplasmodial activity.
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Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities.
Donald Bierer,Diana M. Fort,C. D. Mendez,J. Luo,P. A. Imbach,L. G. Dubenko,Shivanand D. Jolad,R. E. Gerber,Joane Litvak,Qing Lu,Pingsheng Zhang,M. J. Reed,N. Waldeck,Reimar C. Bruening,B. K. Noamesi,R. F. Hector,T. J. Carlson,S.R. King +17 more
TL;DR: This is the first report that cryptolepine possesses antihyperglycemic properties and its salt forms lower blood glucose in rodent models of type II diabetes.
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Constituents of West African Medicinal Plants XX: Quindoline from Cryptolepis sanguinolenta
D. Dwuma-Badu,John S. K. Ayim,Nicholas I.Y. Fiagbe,Joseph E. Knapp,Paul L. Schiff,David J. Slatkin +5 more
TL;DR: An ethanol extract of the roots of Cryptolepis sanguinolenta afforded, after partitioning and chromatography, the alkaloids quindoline and CSA-3, and the structural elucidation of C SA-3 is currently in progress.
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Die Konstitution des Alkaloids Cryptolepin
TL;DR: In this paper, die Konstitution des Alkaloids Cryptolepin was aufgeklart und im Zusammenhang damit bewiesen, dass das zuerst von Fichter synthetisierte Chindolinsystem [Indolo-3′,2′:2,3-chinolin] auch in Naturprodukten vorkommen kann.
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Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases
Colin W. Wright,J. D. Phillipson,S. O. Awe,G. C. Kirby,D. C. Warhurst,Joëlle Quetin-Leclercq,Luc Angenot +6 more
TL;DR: Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb‐methylharmalane were tested against Plasmodium falciparum in vitro and Cryptolepine found to have moderate antimalarial activity; parasitaemia was suppressed by 80% at 50 mg/kg/day.