A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation.
Yoko Yahata,Yuji Shirakata,Sho Tokumaru,Lujun Yang,Xiuju Dai,Mikiko Tohyama,Teruko Tsuda,Koji Sayama,Masaru Iwai,Masatsugu Horiuchi,Koji Hashimoto +10 more
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TLDR
It is demonstrated, for the first time, that Ang II plays an important role in skin wound healing and that it functions by accelerating keratinocyte and fibroblast migration in a process mediated by HB-EGF shedding.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-05-12 and is currently open access. It has received 125 citations till now. The article focuses on the topics: Keratinocyte migration & Angiotensin II.read more
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Journal ArticleDOI
Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
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Wound re-epithelialization: modulating keratinocyte migration in wound healing.
TL;DR: This review focuses on the mechanisms that regulate keratinocyte migration in the re-epithelialization process and the role of growth factors, cytokines and chemokines, eicosanoids, oxygen tension, antimicrobial peptides, and matrix metalloproteinases.
Journal ArticleDOI
The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation
TL;DR: Increasing evidence now suggests that the EGFR pathway has a major impact on the inflammatory/immune reactions of the skin, in the apparent effort of enhancing innate immune defense while opposing overactivation of keratinocyte pro-inflammatory functions.
Journal ArticleDOI
Potential cellular and molecular causes of hypertrophic scar formation
Willem M. van der Veer,Monica C. T. Bloemen,Magda M. W. Ulrich,Grietje Molema,Paul P. M. van Zuijlen,Esther Middelkoop,Frank B. Niessen +6 more
TL;DR: Following the chronology of normal wound healing, the complex molecular and cellular key processes that may be responsible for hypertrophic scars are unravel, clarify and reorganize.
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International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli
Sadashiva S. Karnik,Hamiyet Unal,Jacqueline R. Kemp,Kalyan C. Tirupula,Satoru Eguchi,Patrick Vanderheyden,Walter G. Thomas +6 more
TL;DR: Findings published in the last 15 years on the structure, pharmacology, signaling, physiology, and disease states related to angiotensin receptors are summarized.
References
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Journal ArticleDOI
Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
Journal Article
Angiotensin II receptors and angiotensin II receptor antagonists.
Pieter B.M.W.M. Timmermans,P. C. Wong,Andrew T. Chiu,William F. Herblin,P. Benfield,David J. Carini,R. J. Lee,Ruth R. Wexler,J. A. M. Saye,Ronald D. Smith +9 more
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
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Production and auto-induction of transforming growth factor-alpha in human keratinocytes.
TL;DR: Analysis of normal skin biopsies using in situ hybridization and immunohistochemistry demonstrates the in vivo presence of TGF-α messenger RNA and protein in the stratified epidermis, suggesting that a mechanism of auto-induction exists.
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EGF receptor ligands
TL;DR: The rapid local capture of TGFα by the EGFR has fundamental biological importance and is a phenomenon that is critical in diverse biological processes such as vulva development in the nematode Caenorhabditis elegans (C. elegans) and hair follicle organization in mammals.