Journal ArticleDOI
A perspective on general direction and challenges facing antimicrobial peptides
Meng Zhu,Peng Liu,Zhongwei Niu +2 more
TLDR
An insight is given into the trends and challenges facing on this particular kind of antimicrobial materials regarding their structures, properties, production and modification, and antimicrobial mechanism.About:
This article is published in Chinese Chemical Letters.The article was published on 2017-04-01. It has received 31 citations till now.read more
Citations
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Journal ArticleDOI
Mini Review on Antimicrobial Peptides, Sources, Mechanism and Recent Applications
TL;DR: This mini review will discuss the sources, mechanism and recent therapeutic applications of antimicrobial peptides in treatment of infectious diseases.
Journal ArticleDOI
Combinatory Therapy Antimicrobial Peptide-Antibiotic to Minimize the Ongoing Rise of Resistance
TL;DR: This article focuses on the main aspects of the combinatory therapy antimicrobial peptide (AMP)-antibiotic to treat infectious diseases.
Journal ArticleDOI
Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities
Priscila Cardoso,Hugh D. Glossop,Thomas G. Meikle,Arturo Aburto-Medina,Charlotte E. Conn,Vijayalekshmi Sarojini,Céline Valéry +6 more
TL;DR: In this paper, a review of the most popular alternatives among basic and applied research scientists, synthetic antimicrobial peptides, is presented, where the authors argue that these basic research advances constitute a solid basis for promising industry translation of rationally designed synthetic peptide antimicrobials, not only as novel drugs against multidrug resistant strains but also as components of emerging antimicrobial biomaterials.
Journal ArticleDOI
Balancing antimicrobial activity with biological safety: bifunctional chitosan derivative for the repair of wounds with Gram-positive bacterial infections
Meng Zhu,Peng Liu,Haigang Shi,Ye Tian,Xiaoyan Ju,Shidong Jiang,Zhuang Li,Man Wu,Zhongwei Niu +8 more
TL;DR: Owing to the balance between the antimicrobial activity and biological safety of CS-G/mPEG, this bifunctional chitosan derivative is promising as an ideal anti-infective wound- repairing material for managing wounds with Gram-positive bacterial infections.
Journal ArticleDOI
The apoptosis of Staphylococcus aureus induced by glycinin basic peptide through ROS oxidative stress response
TL;DR: The results of DNA gel electrophoresis, reactive oxygen species (ROS) production and apoptosis analysis demonstrated the antibacterial mechanism of GBP was a result of increased intracellular ROS and blunted adaptive oxidative stress response in S. aureus.
References
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Journal ArticleDOI
Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
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APD3: the antimicrobial peptide database as a tool for research and education
Guangshun Wang,Xia Li,Zhe Wang +2 more
TL;DR: Newly annotated are AMPs with antibiofilm, antimalarial, anti-protist, insecticidal, spermicidal, chemotactic, wound healing, antioxidant and protease inhibiting properties and various database applications in research and education are summarized.
Journal ArticleDOI
Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action.
TL;DR: In this review, the structures of a number of different Trp- and Arg-rich antimicrobial peptides are examined and some of the major mechanistic studies are presented.
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Describing the mechanism of antimicrobial peptide action with the interfacial activity model.
TL;DR: An "interfacial activity model" is proposed, which is based on an experimentally testable molecular image of AMP-membrane interactions, which may be useful in driving engineering and design of novel AMPs.