Journal ArticleDOI
A review on targeting tumor microenvironment: The main paradigm shift in the mAb-based immunotherapy of solid tumors.
Ayuob Aghanejad,S. Farashi Bonab,Maryam Sepehri,Fatemeh Haghighi,Ali Tarighatnia,Christopher Kreiter,Nader D. Nader,Mohammad Reza Tohidkia +7 more
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TLDR
In this article , the tumor microenvironment (TME) is becoming the great importance of attention to develop innovative strategies based on therapeutic monoclonal antibodies (mAbs), which destroy tumor cells indirectly through targeting vasculature system (e.g., anti-angiogenesis), immune system modulation (i.e., stimulation, suppression, and depletion), the targeting and blocking of stroma-based growth signals (e., cancer-associated fibroblasts), and targeting cancer stem cells, as well as, their effector mechanisms, clinical uses, and relevant mechanisms of resistance.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2022-03-13. It has received 19 citations till now. The article focuses on the topics: Medicine & Tumor microenvironment.read more
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Application of dendritic cells in tumor immunotherapy and progress in the mechanism of anti-tumor effect of Astragalus polysaccharide (APS) modulating dendritic cells: a review.
TL;DR: Astragalus polysaccharide (APS) as mentioned in this paper is the main component of the Chinese herb Astragalis membranaceus and it can promote the expression of surface molecules CD80 and CD86, promote the maturation of DCs, and activate CTL to exert antitumor effects.
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Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy
TL;DR: In this paper , the authors employed a human semi-synthetic phage library for isolation of some scFvs against the extracellular domain of PD-1 protein by panning process.
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Therapeutic bispecific antibodies against intracellular tumor antigens.
TL;DR: In this article , the authors introduce the classification, characteristics, and clinical applications of bsAbs, the theoretical basis for targeting intracellular antigens, delivery systems, and the latest preclinical and clinical advances of BsAbs targeting several intra-cell oncotargets.
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Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment
Paniz Siminzar,Mohammad Reza Tohidkia,Elisabeth Eppard,Nasim Vahidfar,Ali Tarighatnia,Ayuob Aghanejad +5 more
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Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model
TL;DR: In this article , the authors developed a bilateral tumor model based on time-shifted subcutaneous injection of murine Her2+ EO771 tumor cells into immune-competent mice followed by selective irradiation of the primary tumor.
References
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
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Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
TL;DR: It is proposed that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics.
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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Jérôme Galon,Daniela Bruni +1 more
TL;DR: A panel of therapeutic strategies to use, combine and develop to treat hot, altered and cold tumours is provided and the impact of combination therapy on the immune response to convert an immune cold into a hot tumour will be discussed.
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Development of therapeutic antibodies for the treatment of diseases
TL;DR: The preeminent antibody engineering technologies used in the development of therapeutic antibody drugs, such as humanization of monoclonal antibodies, phage display, the human antibody mouse, single B cell antibody technology, and affinity maturation are outlined.
Journal ArticleDOI
Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui +10 more
TL;DR: Molecules, vaccines, antibodies, and CAR-T (chimeric antigen receptor T cell) cells have been developed to specifically target CSCs, and some of these factors are already undergoing clinical trials.