Journal ArticleDOI
A structural model for the cholesterol-phosphatidylcholine complexes in bilayer membranes.
TLDR
A model for the cholesterol-phosphatidylcholine complex is proposed, in which the 3β-hydroxyl group of cholesterol is assumed to engage in hydrogen bonding with the carbonyl oxygen of the fatty acyl groups in phospholipids.Abstract:
Based on the structural properties of phospholipid and cholesterol molecules, and making use of the known structural and motional effects of cholesterol and its analogs on phospholipid bilayers, a model for the cholesterol-phosphatidylcholine complex is proposed. In this model, the 3β-hydroxyl group of cholesterol is assumed to engage in hydrogen bonding with the carbonyl oxygen of the fatty acyl groups in phospholipids. Some specific configurations of the saturated and unsaturated fatty acyl chains of the phospholipid are suggested to participate in van der Waals attractive interactions with the α and β surface of the steroid nucleus.read more
Citations
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Journal ArticleDOI
Fluidity Parameters of Lipid Regions Determined by Fluorescence Polarization
Journal ArticleDOI
Cholesterol and the cell membrane.
TL;DR: Recent studies concerning cholesterol, its behavior and its roles in cell growth provide important new clues to the role of this fascinating molecule in normal and pathological states.
Journal ArticleDOI
Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective.
TL;DR: The motivation for this review arises from the conviction that, as a result of the mass of experimental data and observations collected in recent years, the study of the physical properties of membranes is now entering a new stage of development.
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Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function.
TL;DR: The tendency of certain lipids to self-associate, their asymmetric distribution in SUVs, their preferential association with cholesterol in non-cocrystallizing mixtures, their temperature-induced transitions to the hexagonal phase and their inhibitory effect on penetration of hydrophobic residues of proteins partway into the bilayer can all be explained by their participation in intermolecular hydrogen bonding interactions.
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Chemical stability of liposomes: implications for their physical stability
Mustafa Grit,Daan J.A. Crommelin +1 more
TL;DR: In the first part of this article, chemical and physical stability of aqueous liposome dispersions have been addressed and a HPLC method with a refractive index detector for the analysis of phospholipids from aqueously liposomes dispersions is described.
References
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Journal ArticleDOI
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
TL;DR: The cholesterol controls the fluidity of the hydrocarbon chains of the phospholipid by disruption of the crystalline chain lattice of the gel phase, and by inhibiting the flexing of chains in the dispersed liquid crystalline phase.
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Structural analysis of hydrated egg lecithin and cholesterol bilayers I. X-ray diffraction
TL;DR: Lamellar X-ray diffraction from hydrated multilayers of a 3:2 molar mixture of egg lecithin and cholesterol has been analysed and molecular models of the bilayer are presented.
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The movement of molecules across lipid membranes: A molecular theory
TL;DR: A model for the flow of molecules through lipid membranes based on thermal fluctuations in the hydrocarbon chains of the membrane lipids results in the formation of conformational isomers, so-called kink-isomers of the hydro carbon chains.
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Structure of oriented lipid bilayers.
Y. K. Levine,M. H. F. Wilkins +1 more
TL;DR: X-ray diffraction studies show that lipid hydrocarbon chains are uniformly packed in bilayers and oriented so that their free ends are near the centre, which provides a model for biological membranes.