Journal ArticleDOI
A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis.
Hao Chang,Mengjia Zheng,Xiaojun Yu,Aung Than,Razina Z. Seeni,Rongjie Kang,Jingqi Tian,Duong Phan Khanh,Linbo Liu,Peng Chen,Chenjie Xu +10 more
TLDR
A swellable MN patch that can rapidly extract ISF is developed and can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol.Abstract:
Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF from the skin due to its pain-free and easy-to-administrated properties. However, long sampling time is still a serious problem which impedes timely metabolic analysis. In this study, a swellable MN patch that can rapidly extract ISF is developed. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through UV irradiation. Owing to the supreme water affinity of MeHA, this MN patch can extract sufficient ISF in a short time without the assistance of extra devices, which remarkably facilitates timely metabolic analysis. Due to covalent crosslinked network, the MN patch maintains the structure integrity in the swelling hydrated state without leaving residues in skin after usage. More importantly, the extracted ISF metabolites can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol. Given the recent trend of easy-to-use point-of-care devices for personal healthcare monitoring, this study opens a new avenue for the development of MN-based microdevices for sampling ISF and minimally invasive metabolic detection.read more
Citations
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Journal ArticleDOI
Recent advances of microneedles for biomedical applications: drug delivery and beyond.
TL;DR: In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP).
Journal ArticleDOI
Mechanisms of sampling interstitial fluid from skin using a microneedle patch.
TL;DR: This study designs a patch containing microscopic needles that puncture into superficial layers of skin and thereby enable withdrawal of interstitial fluid through micropores in a simple, minimally invasive manner, and designs an MN patch prototype to sample ISF using suction as the driving force.
Journal ArticleDOI
Recent advances in photo-crosslinkable hydrogels for biomedical applications.
TL;DR: This review article discusses the recent advances of the most common photo-crosslinkable hydrogels, including poly(ethylene glycol) diacrylate, gelatin methACryloyl and methacrylated hyaluronic acid, for various biomedical applications.
Journal ArticleDOI
Advances in Antimicrobial Microneedle Patches for Combating Infections.
Rezvan Jamaledin,Cynthia K.Y. Yiu,Ehsan Nazarzadeh Zare,Li Na Niu,Raffaele Vecchione,Guojun Chen,Zhen Gu,Franklin R. Tay,Pooyan Makvandi,Pooyan Makvandi,Pooyan Makvandi +10 more
TL;DR: In the present review, skin anatomy and its barriers along with skin infection are discussed, and potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined.
Journal ArticleDOI
Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs.
Hazhir Teymourian,Marc Parrilla,Juliane R. Sempionatto,Noelia Felipe Montiel,Abbas Barfidokht,Robin Van Echelpoel,Karolien De Wael,Joseph Wang +7 more
TL;DR: Wearable electrochemical sensors capable of noninvasive monitoring of chemical markers represent a rapidly emerging digital-health technology that addresses the growing demand for personalized medicine, toward improved therapeutic outcomes while minimizing the side effects of drugs and the related medical expenses.
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