Journal ArticleDOI
A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research
TLDR
Despite traditional claims, insufficient scientific validation for the treatment of insomnia, dementia, epilepsy, rheumatoid arthritis, asthma, spleen disorder, puerperal fever and leprosy, necessitate future investigations in this direction.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2020-01-30. It has received 80 citations till now. The article focuses on the topics: Spleen disorder.read more
Citations
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The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens.
Amin Thawabteh,Salma Juma,Mariam Bader,Donia Karaman,Laura Scrano,Sabino Aurelio Bufo,Rafik Karaman +6 more
TL;DR: The medical use of natural alkaloids isolated from a variety of plants and utilized by humans as antibacterial, antiviral, antifungal and anticancer agents is covered.
Journal ArticleDOI
Natural Molecules Targeting Thioredoxin System and Their Therapeutic Potential
Junmin Zhang,Junmin Zhang,Dongzhu Duan,Dongzhu Duan,Alsiddig Osama,Alsiddig Osama,Jianguo Fang,Jianguo Fang +7 more
TL;DR: The introduction of natural small molecules with potential therapeutic applications, especially the anticancer activity, are focused on, and their mechanisms of pharmacological actions via interfering with the thioredoxin system are reviewed.
Journal ArticleDOI
Synthesis, optimization and characterization of silver nanoparticles using the catkin extract of Piper longum for bactericidal effect against food-borne pathogens via conventional and mathematical approaches.
Hui Huang,Kuizhong Shan,Jingbing Liu,Xiaoxin Tao,Sivalingam Periyasamy,Siva Durairaj,Ziyu Jiang,Joe Antony Jacob +7 more
TL;DR: The results indicate that nanoparticles of silver synthesized using catkin extract of P. longum can be exploited towards the development of potential antibacterial agents.
Journal ArticleDOI
Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.
Peng Zhu,Peng Zhu,Jianqiang Qian,Zhongyuan Xu,Chi Meng,Ji Liu,Wenpei Shan,Weizhong Zhu,Wang Yongjun,Yumin Yang,Wei Zhang,Yanan Zhang,Yong Ling,Yong Ling +13 more
TL;DR: Compound 9m could be a promising candidate for the treatment of drug-resistant cancer cells and, as such, warrants further investigation.
Journal ArticleDOI
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
Jianqiang Qian,Zhongyuan Xu,Chi Meng,Ji Liu,Pei Ling Hsu,Li Yangyang,Weizhong Zhu,Yumin Yang,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee,Yanan Zhang,Yong Ling,Yong Ling +13 more
TL;DR: 2c is a promising anti-breast cancer candidate warranting further investigation and showed 12-fold higher inhibitory activity against the thioredoxin reductase (TrxR) than PL and surpressed the expression of TrxR1 protein in breast cancer cells and inhibited TrXR enzymatic activity.
References
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Journal ArticleDOI
The pathogenesis of rheumatoid arthritis.
Iain B. McInnes,Georg Schett +1 more
TL;DR: The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
Book
Trease and Evans' Pharmacognosy
TL;DR: The scope and practice of pharmacognosy, the study of medicinal plants and animal-derived drugs, and the search for naturally-derived anticancer agents and miscellaneous glycosides are explained.
Journal ArticleDOI
Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview.
TL;DR: This review attempts to demonstrate an overview of flavonoids and other phenolic compounds as the interesting alternative sources for pharmaceutical and medicinal applications.
Journal ArticleDOI
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
TL;DR: The latest advances in immunotherapy are highlighted and the role that it will have in the future of cancer treatment, including settings for which testing combination strategies and 'armoured' CAR T cells are recommended are discussed.
Journal ArticleDOI
Tansley Review No. 112
Christine H. Foyer,Graham Noctor +1 more
TL;DR: This review considers photosynthesis as a whole-cell process, in which O2 and AOS are involved in reactions at both photosystems, enzyme regulation in the chloroplast stroma, photorespiration, and mitochondrial electron transport in the light, and oxidants and antioxidants are discussed as metabolic indicators of redox status, acting as sensors and signal molecules leading to acclimatory responses.