Journal ArticleDOI
Abnormalities of chromosome No. 17 in myeloproliferative disorders
TLDR
It is suggested that loss of 17p is a highly nonrandom event related to blastic crisis in CML and the terminal phase in other myeloid leukemias.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 1982-02-01. It has received 79 citations till now. The article focuses on the topics: Isochromosome & Preleukemia.read more
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Journal ArticleDOI
Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia
TL;DR: It is suggested that all these aberrations, occurring in >5% of CML with secondary changes, should be denoted major route abnormalities, except for slightly lower frequencies of the most common changes in the latter group.
Journal ArticleDOI
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Jian Cheng,M. Haas +1 more
TL;DR: The data show that at least 6 of 10 leukemic T-cell lines examined may have lost the normal function of a known tumor suppressor gene, suggesting that this class of genes serves a critical role in the generation of fully tumorigenic leukedmic T cells.
Journal ArticleDOI
The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses
TL;DR: Evidence began to emerge that the function of wild-type ~53 might be to negatively regulate the growth of some cells and that p53 appears to act as a tumor suppressor gene under some circumstances (Mowat et al, 1985; Finlay et al., 1989; Baker et a/., 1989).
Journal ArticleDOI
Cytogenetic Abnormalities Predict Clinical Outcome in Non-Hodgkin Lymphoma
Ellis G. Levine,Diane C. Arthur,Glauco Frizzera,Bruce A. Peterson,David D. Hurd,Clara D. Bloomfield +5 more
TL;DR: It is concluded that chromosomal abnormalities are predictive of clinical outcome in malignant lymphoma.
References
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Journal Article
Nonrandom Chromosomal Abnormalities in Acute Nonlymphocytic Leukemia in Patients Treated for Hodgkin Disease and Non-Hodgkin Lymphomas
TL;DR: Chromosomal analyses of myeloid cells were performed on ten patients who had acute nonlymphocytic leukemia (ANLL) following treatment for malignant lymphoma, finding the chromosomal pattern of hypodiploid cell lines found in ANLL de novo was similar to that occurring in treated lymphoma.
Journal ArticleDOI
Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL)
TL;DR: Banding analysis has afforded the first reliable approach towards ascertaining karyotypic evolution in ALL, which was achieved in eight cases of the present study.
Journal ArticleDOI
"Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity
TL;DR: Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes, which are regarded as comprising a distinct clinical, ultrastructural, and cytogenetic entity that are chosen to call "microgranular" acute Promyelocytic leukemia.