Accentuated osseointegration in osteogenic nanofibrous coated titanium implants
Siddhartha Das,Kanchan P. Dholam,Sandeep V Gurav,Kiran Bendale,Arvind Ingle,Bhabani Mohanty,Pradip Chaudhari,Jayesh R. Bellare +7 more
TLDR
The findings of the present study confirm that osteogenic nanofibrous coating significantly increases the magnitude of osteogenesis in the peri-implant zone and favours the dynamics of osseointegration.Abstract:
Anchoring of endosseous implant through osseointegration continues to be an important clinical need. Here, we describe the development of superior endosseous implant demonstrating enhance osseointegration, achieved through surface modification via coating of osteogenic nanofibres. The randomized bio-composite osteogenic nanofibres incorporating polycaprolactone, gelatin, hydroxyapatite, dexamethasone, beta-glycerophosphate and ascorbic acid were electrospun on titanium implants mimicking bone extracellular matrix and subsequently induced osteogenesis by targeting undifferentiated mesenchymal stem cells present in the peri-implant niche to regenerate osseous tissue. In proof-of-concept experiment on rabbit study models (n = 6), micro-computed tomography (Micro-CT), histomorphometric analysis and biomechanical testing in relation to our novel osteogenic nanofibrous coated implants showed improved results when compared to uncoated controls. Further, no pathological changes were detected during gross examination and necropsy on peri-implant osseous tissues regenerated in response to such coated implants. The findings of the present study confirm that osteogenic nanofibrous coating significantly increases the magnitude of osteogenesis in the peri-implant zone and favours the dynamics of osseointegration.read more
Citations
More filters
Journal ArticleDOI
Powder metallurgy with space holder for porous titanium implants: A review
Alejandra Rodríguez-Contreras,Miquel Punset,José A. Calero,Francisco Javier Gil,Elisa Rupérez,José María Manero +5 more
TL;DR: In this article, powder metallurgy with space holder (SH) is a powerful technology used to produce porous Ti structures, it is discussed its potential for the fabrication of medical devices from the perspectives of both design and manufacture.
Journal ArticleDOI
Robust Hydroxyapatite Coating by Laser‐Induced Hydrothermal Synthesis
Seung-Hoon Um,Seung-Hoon Um,Yong-Woo Chung,Youngmin Seo,Hyunseon Seo,Myoung-Ryul Ok,Yu Chan Kim,Yu Chan Kim,Hyung-Seop Han,Justin J. Chung,James R. Edwards,Hojeong Jeon,Hojeong Jeon +12 more
Journal ArticleDOI
Tannin-reinforced iron substituted hydroxyapatite nanorods functionalized collagen-based composite nanofibrous coating as a cell-instructive bone-implant interface scaffold
Zahid Hussain,Ismat Ullah,Xingzhui Liu,Wenqi Shen,Pi Ding,Yajie Zhang,Tong Gao,Mojtaba Mansoorianfar,Tian Gao,Renjun Pei +9 more
TL;DR: In this article , the inorganic-organic nanofibers were coated onto an implant surface using electrospinning and the results support that metal-phenolic networks on nanorods regulate interfacial interactions, nanorod cytocompatibility, antioxidant potential, and phase compatibility between organic and inorganic materials of scaffolds.
Journal ArticleDOI
Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections
Viviane Ständert,Kai Borcherding,Nicole Bormann,Gerhard Schmidmaier,Ingo Grunwald,Britt Wildemann,Britt Wildemann +6 more
TL;DR: In this article, a mechanically stable porous structure was created on a titanium surface using laser treatment and metallic silver particles were embedded in a hydrophilic titanium oxide layer on top to enable better osteointegration.
Journal ArticleDOI
Biological effects, applications and strategies of nanomodification of dental metal surfaces
TL;DR: In this paper, a review characterizes current applications of nanotechnology for dental metal surface modification, with discussion of the resulting materials' biocompatibility, interactions with cells and antibacterial activity.
References
More filters
Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
A 15-year study of osseointegrated implants in the treatment of the edentulous jaw
TL;DR: The clinical results achieved with bridges on osseointegrated fixtures fulfill and exceed the demands set by the 1978 Harvard Conference on successful dental implantation procedures.
Journal ArticleDOI
Electrospinning: A Fascinating Method for the Preparation of Ultrathin Fibers
TL;DR: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers, applicable to virtually every soluble or fusible polymer.
Journal Article
The long-term efficacy of currently used dental implants: a review and proposed criteria of success.
TL;DR: Criteria for the evaluation of dental implant success are proposed and an attempt has been made to standardize the basis for comments on each type of implant.
Journal ArticleDOI
Osseointegrated Titanium Implants: Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man
TL;DR: It is concluded that the technique of osseointegration is a reliable type of cement-free bone anchorage for permanent prosthetic tissue substitutes in man for various bone restorative procedures.