Actin networks regulate the cell membrane permeability during electroporation.
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TLDR
The results suggest that the current theoretical models of electroporation should be advanced further by including the contributions of the cytoskeletal networks on the cell membrane permeability during the delivery of exogenous materials.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2021-01-01 and is currently open access. It has received 37 citations till now. The article focuses on the topics: Electroporation & Cytoskeleton.read more
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In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale.
TL;DR: This review of in-cell structural biology by NMR spectroscopy is meant to deliver comprehensive but accessible information, with advanced technical details and reflections on the methods, the nature of the results, and the future of the field.
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Coupling of mechanical deformation and electromagnetic fields in biological cells
TL;DR: In this paper , the authors report on several major advances in elucidating the physics of biological matter and survey new challenges pertinent to cellular biomechanics, and present a review of some of the major advances.
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OUP accepted manuscript
TL;DR: In this article , a review of the principles and biophysics of PEF ablation is presented, which aims to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
Journal ArticleDOI
An Ultra-Simple Charge Supplementary Strategy for High Performance Rotary Triboelectric Nanogenerators.
Hongqing Feng,Yuan Bai,Yuan Bai,Lei Qiao,Zhe Li,Engui Wang,Engui Wang,Shengyu Chao,Xuecheng Qu,Yu Cao,Zhuo Liu,Xi Han,Ruizeng Luo,Yizhu Shan,Zhou Li,Zhou Li +15 more
TL;DR: In this paper, a simple and delicate structure was developed for the rotary triboelectric nanogenerators (rTENGs) to achieve ultra-high durability with the 2.3 kV voltage output 100% maintained after 1 000 000 cycles.
Journal ArticleDOI
Cardiac ablation with pulsed electric fields: principles and biophysics.
TL;DR: An understanding of the principles and biophysics of PEF ablation is provided to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
References
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Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial.
Kayvon Modjarrad,Christine C. Roberts,Kristin Mills,Amy R. Castellano,Kristopher Paolino,Karuppiah Muthumani,Emma L. Reuschel,Merlin L. Robb,Trina Racine,Myoung Don Oh,Claude Lamarre,Faraz I. Zaidi,Jean D. Boyer,Sagar B. Kudchodkar,Moonsup Jeong,Janice Darden,Young K. Park,Paul T. Scott,Celine Remigio,Ajay P. Parikh,Megan C. Wise,Ami Patel,Elizabeth K. Duperret,Kevin Kim,Hyeree Choi,Scott White,Mark L. Bagarazzi,Jeanine M. May,Deborah Kane,Hyo Jin Lee,Gary P. Kobinger,Nelson L. Michael,David B. Weiner,Stephen J. Thomas,Joel N. Maslow +34 more
TL;DR: The primary outcome of the study was safety, assessed in all participants who received at least one study treatment and for whom post-dose study data were available, during the vaccination period with follow-up through to 48 weeks after dose 3.
Journal ArticleDOI
In vivo electroporation for gene therapy.
Loree C. Heller,Richard Heller +1 more
TL;DR: This minireview is limited in scope to the most recent studies using in vivo EP for delivery of plasmid DNA, and focuses on those studies that demonstrated a clear therapeutic response with the potential to be used clinically.
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Spatiotemporally controlled single cell sonoporation
TL;DR: This paper presents unique approaches to enable control and quantification of ultrasound-mediated cell membrane disruption, or sonoporation, at the single-cell level and achieved spatiotemporally controlled delivery with subcellular precision and calcium signaling in targeted cells by selective excitation of microbubbles.
Journal ArticleDOI
Effect of electric field induced transmembrane potential on spheroidal cells: theory and experiment.
Blaž Valič,Muriel Golzio,Mojca Pavlin,Anne Schatz,Cécile Faurie,Bruno Gabriel,Justin Teissié,Marie-Pierre Rols,Damijan Miklavčič +8 more
TL;DR: Theoretical and experimental results show that permeabilization is not only a function of electric field intensity and cell size but also of cell shape and orientation, and the surface exposed to the transmembrane potential above the threshold value was calculated.
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Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery
Emmanuel Dauty,Alan S. Verkman +1 more
TL;DR: The actin cytoskeleton is identified as a major barrier restricting cytoplasmic transport of non-complexed DNA in non-viral gene transfer in mammalian cells.