Activation of human matrix metalloproteinases by various bacterial proteinases
Tatsuya Okamoto,Takaaki Akaike,Moritaka Suga,Sumio Tanase,Hidechika Horie,Seiya Miyajima,Masayuki Ando,Yoshio Ichinose,Hiroshi Maeda +8 more
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TLDR
Results indicate that bacterial proteinases may play an important role in tissue destruction and disintegration of extracellular matrix at the site of infections.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-02-28 and is currently open access. It has received 169 citations till now. The article focuses on the topics: Thermolysin & Matrix metalloproteinase.read more
Citations
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Is there new hope for therapeutic matrix metalloproteinase inhibition
TL;DR: The recent advances made in understanding the role of MMPs in inflammatory diseases and the therapeutic potential of M Parliamentary metalloproteinases inhibition in those conditions are discussed.
Journal ArticleDOI
Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications.
TL;DR: The phenomenon of "enhanced permeability and retention effect" observed in cancer tissue for macromolecules and lipids is coined "EPR effect", which is now widely accepted as a gold standard for anticancer drug designing to seek more cancer-selective targeting usingmacromolecular drugs.
Journal ArticleDOI
The cell biology of leukocyte-mediated proteolysis.
TL;DR: This work has identified several mechanisms by which inflammatory cells can degrade extracellular proteins in a milieu that contains high‐affinity proteinase inhibitors.
Journal ArticleDOI
Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation
Tatsuya Okamoto,Tatsuya Okamoto,Takaaki Akaike,Tomohiro Sawa,Yoichi Miyamoto,Albert van der Vliet,Hiroshi Maeda +6 more
TL;DR: In this article, peroxynitrite and GSH-dependent proMMP activation was found to be a potent oxidizing agent formed during inflammatory processes, and extensive S-glutathiolation of the pro-MMP protein occurred during activation.
Infection and Drug Resistance
TL;DR: Dr Benjamin A H Jensen Dr Aarabi Dr Mera A Ababneh Dr Albert Abaka-Yawson Dr Mohamed Salah Abassi Dr Getahun Abate Dr Tarek Mohamed Abd ElAziz Dr Rehab M Abd El-Baky Dr Amir Abdoli Dr Akebe Luther King Abia Dr Fatma Ben Abid Prof Dr Khaled M Aboshanab Mr Ashenafi Abossie Dr Abouelfetouh Dr Maja Abram
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.
TL;DR: Small amounts of myoglobin, beta-lactoglobulin, and other proteins and peptides can be spotted or electroblotted onto polyvinylidene difluoride membranes, stained with Coomassie Blue, and sequenced directly, suggesting that PVDF membranes are superior supports for sequence analysis of picomole quantities of proteins purified by gel electrophoresis.
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The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.
H E Van Wart,H Birkedal-Hansen +1 more
TL;DR: Observations support the view that the cysteine-switch mechanism is applicable to all members of this gene family and offers the opportunity for multiple modes of physiological activation of these important enzymes.
Journal ArticleDOI
Evolutionary families of peptidases
Neil D. Rawlings,Alan J. Barrett +1 more
TL;DR: It is suggested that the classification by families could be used as an extension of the current classification by catalytic type, and some of these contain members with quite diverse peptidase activities.
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