Journal ArticleDOI
Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing
Edwin C. M. Mariman,Chris A.G. van Eekelen,Rita J. Reinders,Anton Berns,Walther J. van Venrooij +4 more
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TLDR
These results further support the concept that the nuclear matrix may function in the localization and the structural organization of (viral) heterogeneous nuclear RNA during its processing.About:
This article is published in Journal of Molecular Biology.The article was published on 1982-01-05. It has received 109 citations till now. The article focuses on the topics: RNA & RNA-binding protein.read more
Citations
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Journal ArticleDOI
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus
Xiang-Dong Fu,Tom Maniatis +1 more
TL;DR: A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for splicedosome assembly, which is highly concentrated in discrete regions within the nucleus.
Journal ArticleDOI
Macromolecular domains within the cell nucleus.
TL;DR: A chronology of key events and events leading to the formation of the HJ-Uridine Incorporation, In Situ Nick Translation, and subsequent efforts to correct for these errors.
Journal ArticleDOI
Associations between distinct pre-mRNA splicing components and the cell nucleus.
TL;DR: These studies reveal a dynamic pattern of assembly and disassembly of the splicing factor SC‐35 into discrete nuclear structures that colocalize with interchromatin granules and perichromatin fibrils, which may be nuclear organelles involved in the assembly of spliceosomes, or splicing itself.
Book ChapterDOI
The Origin and Evolution of Retroposons
TL;DR: This chapter describes the origin and evolution of retroposons, a class of dispersed sequences in DNA which appear to have arisen during evolution by a particular mechanism of inserting RNA sequences into chromosomal DNA (retroposition).
Journal ArticleDOI
The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication
TL;DR: The prereplicative sites may serve as a nuclear reservoir for ICP8 not bound to replicating or progeny DNA, which is localized in randomly distributed replication compartments, where it is bound to viral DNA.
References
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Journal ArticleDOI
Are snRNPs involved in splicing
TL;DR: Several lines of evidence are presented that suggest a direct involvement of snRNPs in the splicing of hnRNA molecules, including the observation that the nucleotide sequence at the 5′ end of U1 RNA exhibits extensive complementarity to those across splice junctions in hn RNA molecules.
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Complex splicing patterns of RNAs from the early regions of adenovirus-2
TL;DR: From the large, complex arrays of composite RNA structures, numerous insights into the RNA splicing mechanisms were inferred.
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Identification and characterization of the packaging proteins of core 40S hnRNP particles
TL;DR: The similarity in protein composition of core RNP particles from different cell types is consistent with a conserved particle structure and function in eucaryotes.
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Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate.
TL;DR: It is suggested that protein synthesis stops in this system due to a failure of polypeptide initiation, and the efficiency of messenger RNA translation was estimated by two independent methods, which indicate that each globin messenger RNA was translated about 70 times during a 90-min incubation.
Journal ArticleDOI
A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids
TL;DR: Using electron microscopic RNA loop mapping to determine, to within 200 nucleotides, the chromosome coordinates of the 5′ and 3′ ends of adenovirus type 2 transcripts isolated from the cytoplasm of productively infected human KB cells, the most frequent late RNA loop occurred between coordinates 51.9 and 62.8.