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adverse effects on t(8;21) leukemia in vitro and in vivo AML1-ETO fusion protein and shows potent antitumor activity with low Oridonin, a diterpenoid extracted from medicinal herbs, targets
Chen Zhu,Jue Chen,Long-Jun Gu,Ming Yan,Dong-Er Zhang,Sai Juan Chen,Guang-Biao Zhou,Hui Kang,Lan Wang,Ping Liu,Jun Xie,Feng-Xiang Zhang +11 more
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Caspases: the executioners of apoptosis
TL;DR: The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules, such as RAIDD [receptor-interacting protein (RIP)-associated ICH-1/CED-3-homologous protein with a death domain]/CRADD (caspase and RIP adapter with death domain), which binds to the prodomain of cspase-2 and recruits it to the signalling complex.
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The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial
David Grimwade,Helen Walker,Fiona Oliver,Keith Wheatley,Christine J. Harrison,G Harrison,J. K. H. Rees,Ian Hann,Richard L. Stevens,Alan Kenneth Burnett,Anthony H. Goldstone +10 more
TL;DR: Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR.
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Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
TL;DR: All-trans retinoic acid is an effective inducer for attaining complete remission in APL and no abnormalities in the coagulation parameters were measured, suggesting an absence of any subclinical disseminated intravascular coagulations.
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Apoptosis: a link between cancer genetics and chemotherapy.
TL;DR: Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
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Caspase structure, proteolytic substrates, and function during apoptotic cell death.
TL;DR: These enzymes define a new class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct mammalian family members that account for the majority of cellular and morphological events that occur during cell death.