Journal ArticleDOI
Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology.
Douglas S. Reed,Matthew G. Lackemeyer,Nicole L. Garza,Lawrence J. Sullivan,Donald K. Nichols +4 more
Reads0
Chats0
TLDR
Clinical signs and time to death in all three species were comparable to what has been reported previously for each species after parenteral inoculation with ZEBOV, which will be useful in selection of an animal model for efficacy studies.About:
This article is published in Microbes and Infection.The article was published on 2011-10-01. It has received 80 citations till now. The article focuses on the topics: Petechial rash & Zaire ebolavirus.read more
Citations
More filters
Journal ArticleDOI
The Pathogenesis of Ebola Virus Disease
TL;DR: Major challenges for managing future Ebola epidemics include establishment of early and aggressive epidemic control and earlier and better patient care and treatment in remote, resource-poor areas where Ebola typically reemerges.
Journal ArticleDOI
The non‐human primate model of tuberculosis
TL;DR: While the initial aim of the NHP model was to allow preclinical testing of candidate vaccines and drugs, it is now also being used to study pathogenesis and immune correlates of protection, and advances in this field are discussed in this review.
Journal ArticleDOI
Ebola Virus Shedding and Transmission: Review of Current Evidence.
Pauline Vetter,William A. Fischer,Manuel Schibler,Manuel Schibler,Michael Jacobs,Daniel G. Bausch,Laurent Kaiser,Laurent Kaiser +7 more
TL;DR: An extensive PubMed literature review encompassing the period from discovery of Ebola virus, in 1976, until 1 June 2016 found no strong evidence supporting respiratory or fomite-associated transmission.
Journal ArticleDOI
Considerations in the Use of Nonhuman Primate Models of Ebola Virus and Marburg Virus Infection
TL;DR: Decades of experience working with filovirus-infected NHPs are drawn on to provide a perspective on the importance of various experimental conditions over a variety of experimental conditions.
Journal ArticleDOI
Ebola virus disease in Africa: epidemiology and nosocomial transmission
P. Shears,Tim O'Dempsey +1 more
TL;DR: Recommendations from previous outbreaks include improved disease surveillance to enable more rapid health responses, the wider availability of personal protective equipment, and greater international preparedness.
References
More filters
Journal ArticleDOI
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses.
Steven Jones,Heinz Feldmann,Heinz Feldmann,Ute Ströher,Ute Ströher,Joan B. Geisbert,Lisa Fernando,Allen Grolla,Hans-Dieter Klenk,Nancy J. Sullivan,Viktor E. Volchkov,Elizabeth A. Fritz,Kathleen M. Daddario,Lisa E. Hensley,Peter B. Jahrling,Thomas W. Geisbert +15 more
TL;DR: The data suggest that these replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors are safe and highly efficacious in a relevant animal model.
Journal ArticleDOI
Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Thomas W. Geisbert,Lisa E. Hensley,Tom Larsen,Howard A. Young,Douglas S. Reed,Joan B. Geisbert,Dana P. Scott,Elliott Kagan,Peter B. Jahrling,Kelly J. Davis +9 more
TL;DR: In this paper, 21 cynomolgus monkeys were experimentally infected with EBOV and examined sequentially over a 6-day period to investigate the pathological events of infection that lead to death.
Journal ArticleDOI
Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates
Nancy J. Sullivan,Thomas W. Geisbert,Joan B. Geisbert,Ling Xu,Zhi Yong Yang,Mario Roederer,Richard A. Koup,Peter B. Jahrling,Gary J. Nabel +8 more
TL;DR: The development of accelerated vaccination against Ebola virus in non-human primates provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses.
Journal ArticleDOI
Transmission of Ebola Hemorrhagic Fever: A Study of Risk Factors in Family Members, Kikwit, Democratic Republic of the Congo, 1995
TL;DR: After adjusting for direct contact and exposure to body fluids, adult family members, those who touched the cadaver, and those who were exposed during the late hospital phase were at additional risk of EHF.
Journal ArticleDOI
Preliminary report: isolation of Ebola virus from monkeys imported to USA.
Peter B. Jahrling,Thomas W. Geisbert,E. D. Johnson,C. J. Peters,D. W. Dalgard,William C. Hall +5 more
TL;DR: This incident, the first in which a filovirus has been isolated from non-human primates without deliberate infection, raises the possibility that cynomolgus monkeys could be a reservoir of Ebola virus infection.
Related Papers (5)
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Xiangguo Qiu,Gary Wong,Jonathan Audet,Alexander Bello,Lisa Fernando,Judie B. Alimonti,Hugues Fausther-Bovendo,Haiyan Wei,Jenna Aviles,Ernie Hiatt,Ashley K. Johnson,Josh Morton,Kelsi Swope,Ognian Bohorov,Natasha Bohorova,Charles Goodman,Do Jin Kim,Michael H. Pauly,Jesus Velasco,James Pettitt,Gene G. Olinger,Kevin J. Whaley,Bianli Xu,James E. Strong,Larry Zeitlin,Gary P. Kobinger +25 more