Journal ArticleDOI
Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial
Matthew J. Budoff,Naser Ahmadi,Khawar M. Gul,Sandy T. Liu,Ferdinand Flores,Jima Tiano,Junichiro Takasu,Elizabeth C. Miller,Sotirios Tsimikas +8 more
TLDR
AGE+S is associated with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.About:
This article is published in Preventive Medicine.The article was published on 2009-08-01. It has received 132 citations till now. The article focuses on the topics: B vitamins & Lipid profile.read more
Citations
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Journal ArticleDOI
Molecular Biology of Atherosclerosis
TL;DR: Key signaling pathways are presented to provide a context for the gene manipulations summarized herein and will undoubtedly provide a rich resource for future innovation toward intervention and prevention of the number one cause of death in the modern world.
Journal ArticleDOI
Coronary artery calcification: pathogenesis and prognostic implications.
Mahesh V. Madhavan,Madhusudhan Tarigopula,Gary S. Mintz,Akiko Maehara,Gregg W. Stone,Philippe Généreux,Philippe Généreux +6 more
TL;DR: Although drug-eluting stents and devices for plaque modification have modestly improved outcomes in calcified vessels, adverse event rates are still high.
Journal ArticleDOI
Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases.
Andreja Trpkovic,Ivana Resanovic,Julijana Stanimirovic,Djordje Radak,Shaker A. Mousa,Desanka Cenic-Milosevic,Danimir Jevremovic,Esma R. Isenovic +7 more
TL;DR: In this paper, the value of circulating OxLDLD as a biomarker of CVD has been discussed and three enzyme-linked immunosorbent assays (4E6, DLH3, and E06) using murine monoclonal antibodies for determination of oxLDL blood levels have been developed However, none of these assays are currently approved for routine clinical practice.
Journal ArticleDOI
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Rodrigo Arreola,Saray Quintero-Fabián,Rocío Ivette López-Roa,Enrique Octavio Flores-Gutierrez,Juan Pablo Reyes-Grajeda,Lucrecia Carrera-Quintanar,Daniel Ortuño-Sahagún +6 more
TL;DR: The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system as discussed by the authors.
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Coronary artery calcium progression: an important clinical measurement? A review of published reports.
John W. McEvoy,Michael J. Blaha,Andrew P. DeFilippis,Matthew J. Budoff,Khurram Nasir,Khurram Nasir,Roger S. Blumenthal,Steven R. Jones +7 more
TL;DR: It is found that CAC progression correlates with worsening atherosclerosis and may facilitate prediction of future cardiac events and support the notion that slowing CAC progress with therapeutic interventions might provide prognostic benefit.
References
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Journal ArticleDOI
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
Journal ArticleDOI
Prediction of Coronary Heart Disease Using Risk Factor Categories
Peter W.F. Wilson,Ralph B. D'Agostino,Daniel Levy,Albert M. Belanger,Halit Silbershatz,William B. Kannel +5 more
TL;DR: A simple coronary disease prediction algorithm was developed using categorical variables, which allows physicians to predict multivariate CHD risk in patients without overt CHD.
Journal ArticleDOI
Quantification of coronary artery calcium using ultrafast computed tomography
Arthur S. Agatston,Warren R. Janowitz,Warren R. Janowitz,Frank J. Hildner,Frank J. Hildner,N R Zusmer,N R Zusmer,Manuel Viamonte,Manuel Viamonte,Robert Detrano,Robert Detrano +10 more
TL;DR: In this article, the authors used ultrafast computed tomography (UCT) to detect and quantify coronary artery calcium levels in 584 subjects (mean age 48 +/- 10 years) with and without clinical coronary artery disease.
Journal ArticleDOI
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
TL;DR: The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
Journal ArticleDOI
Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
Robert Detrano,Alan D. Guerci,J. Jeffrey Carr,Diane E. Bild,Gregory L. Burke,Aaron R. Folsom,Kiang Liu,Steven Shea,Moyses Szklo,David A. Bluemke,Daniel H. O'Leary,Russell P. Tracy,Karol E. Watson,Nathan D. Wong,Richard A. Kronmal +14 more
TL;DR: The coronary calcium score is a strong predictor of incident coronary heart disease and provides predictive information beyond that provided by standard risk factors in four major racial and ethnic groups in the United States.