Aging and Arterial Stiffness
Hae Young Lee,Byung Hee Oh +1 more
TLDR
Vascular aging is an independent risk factor for cardiovascular disease, from atherosclerosis to target organ damage, including coronary artery disease, stroke and heart failure, and various strategies, especially controlling hypertension, show benefit in preventing, delaying or attenuating vascular aging.Abstract:
Arterial walls stiffen with age. The most consistent and well-reported changes are luminal enlargement with wall thickening and a reduction of elastic properties at the level of large elastic arteries. Longstanding arterial pulsation in the central artery causes elastin fiber fatigue and fracture. Increased vascular calcification and endothelial dysfunction are also characteristic of arterial aging. These changes lead to increased pulse wave velocity, especially along central elastic arteries, and increases in systolic blood pressure and pulse pressure. Vascular aging is accelerated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Vascular aging is an independent risk factor for cardiovascular disease, from atherosclerosis to target organ damage, including coronary artery disease, stroke and heart failure. Various strategies, especially controlling hypertension, show benefit in preventing, delaying or attenuating vascular aging.read more
Citations
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Journal ArticleDOI
Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association
Raymond R. Townsend,Ian B. Wilkinson,Ernesto L. Schiffrin,Alberto Avolio,Julio A. Chirinos,John R. Cockcroft,Kevin S. Heffernan,Edward G. Lakatta,Carmel M. McEniery,Gary F. Mitchell,Samer S. Najjar,Wilmer W. Nichols,Elaine M. Urbina,Thomas Weber +13 more
TL;DR: The field of arterial stiffness investigation, which has exploded over the past 20 years, has proliferated without logistical guidance for clinical and research studies, and questions that remain to be addressed in this field are addressed.
Journal ArticleDOI
Potential Autonomic Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study
Roger B. Fillingim,Richard Ohrbach,Joel D. Greenspan,Charles Knott,Ronald Dubner,Eric Bair,Cristina Baraian,Gary D. Slade,William Maixner +8 more
TL;DR: Psychosocial findings from the baseline case-control study of the OPPERA Study, a large prospective cohort study designed to discover causal determinants of TMD pain, indicate significant differences between TMD cases and TMD-free controls across multiple psychossocial constructs, and future analyses will determine whether these psychosocial factors increase risk for new onset TMD.
Journal ArticleDOI
Ageing, metabolism and cardiovascular disease
TL;DR: A dynamic interplay between emerging pathways such as FOXOs, AMPK, SIRT1, p66Shc, JunD and NF‐kB are described, which will provide the background for attractive molecular targets to prevent age‐driven pathology in the vasculature and the heart.
Journal ArticleDOI
The Glymphatic System and Waste Clearance with Brain Aging: A Review
TL;DR: This review aims to provide an overview and discussion of the concept behind the glymphatic system, current evidence, and controversies, while specifically focusing on the consequences of aging and evidence of its existence in human brain.
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Cardiovascular Disease in COPD: Mechanisms
John D. Maclay,William MacNee +1 more
TL;DR: The potential mechanisms that link COPD to an increased risk of cardiovascular disease are discussed and alternatives to smoking, low socioeconomic class, and a sedentary lifestyle are considered.
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Expert consensus document on arterial stiffness: methodological issues and clinical applications
Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +9 more
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Journal Article
Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary
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