AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.
Natsumi Maehara,Kaori Taniguchi,Ami Okuno,Hideaki Ando,Aika Hirota,Zhiheng Li,Ching-Ting Wang,Satoko Arai,Toru Miyazaki,Toru Miyazaki,Toru Miyazaki +10 more
TLDR
In this paper, the authors reported that AIM (or CD5L) protein reduces sterile inflammation by attenuating DAMPs and that aIM administration ameliorates the deleterious effects of ischemic stroke.About:
This article is published in Cell Reports.The article was published on 2021-09-14 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Animal mortality.read more
Citations
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Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1
Kyohei Matsuura,Natsumi Maehara,Ai Hirota,Ayaka Eguchi,Keisuke Yasuda,Kaori Taniguchi,Akemi Nishijima,Nobuyuki Matsuhashi,Yoshiyuki Shiga,Rumi Ishii,Yasuhiro Iguchi,Kazunari Tanabe,Satoko Arai,Toru Miyazaki +13 more
TL;DR: Wang et al. as discussed by the authors showed that AIM (also called CD5L) suppresses stone development and improves stone-associated physical damages, which could be the basis for the development of a comprehensive therapy against kidney stone disease.
Journal ArticleDOI
Lupus Susceptibility Loci Predispose Mice to Clonal Lymphocytic Responses and Myeloid Expansion
TL;DR: This dataset provides novel mechanistic insight into the pathophysiology of a spontaneous model of lupus, highlighting potential therapeutic targets for autoantibody-mediated disease.
Journal ArticleDOI
Association between inflammatory biomarkers and cognitive aging
Yuan Fang,Margaret F. Doyle,Jiachen Chen,Michael L. Alosco,Jesse Mez,Claudia L. Satizabal,Wei Qiao Qiu,Joanne M. Murabito,Kathryn L. Lunetta +8 more
TL;DR: Higher circulating levels of soluble CD40L and MPO, markers of immune cell activation, were associated with poorer performance on neuropsychological tests, while higher CD5L, a key regulator of inflammation, was associated with smaller total brain volumes.
Journal ArticleDOI
Serum levels of immunoglobulin M‐free inhibitors of macrophage/CD5L as a predictive and early diagnostic marker for nonalcoholic steatohepatitis‐associated hepatocellular carcinoma
Takeshi Okanoue,Kanji Yamaguchi,Toshihide Shima,Yasuhide Mitsumoto,Masayuki Mizuno,Takayuki Katayama,Yuya Seko,Michihisa Moriguchi,Atsushi Umemura,Yoshito Itoh,Toru Miyazaki +10 more
TL;DR: During the development of NASH-HCC, AIM activation in blood appears to start even before HCC is diagnostically detectable, suggesting that the serum IgM-free AIM levels could be a new, sensitive biomarker for latent NASH -HCC.
References
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Origin and Physiological Roles of Inflammation
TL;DR: This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.
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Mechanisms of phagocytosis in macrophages
Alan Aderem,David M. Underhill +1 more
TL;DR: Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
Journal ArticleDOI
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen,Gabriel Núñez +1 more
TL;DR: The triggers and receptor pathways that result in sterile inflammation and its impact on human health are reviewed.
Journal ArticleDOI
The immunology of stroke: from mechanisms to translation
TL;DR: Gaining a better understanding of the reciprocal interaction between the immune system and the ischemic brain is essential to harness the full therapeutic potential of the immunology of stroke.
Journal ArticleDOI
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
TL;DR: Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.
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