Journal ArticleDOI
Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens.
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TLDR
The present experiments show that the locomotor stimulatory effects of ghrelin are mediated via ventral tegmental nAChR, but neither the alpha(4)beta(2) (using dihydro-beta-erythroidine) nor thealpha(7) ( using methyllycaconitine) subtypes appears to be involved.About:
This article is published in European Neuropsychopharmacology.The article was published on 2008-07-01. It has received 78 citations till now. The article focuses on the topics: Ghrelin & Ventral tegmental area.read more
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Journal ArticleDOI
Requirement of central ghrelin signaling for alcohol reward
Elisabet Jerlhag,Emil Egecioglu,Sara Landgren,Nicolas Salomé,Markus Heilig,Diederik Moechars,Rakesh Datta,Daniel Perrissoud,Suzanne L. Dickson,Jörgen A. Engel +9 more
TL;DR: Central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol.
Journal ArticleDOI
Ghrelin Increases Intake of Rewarding Food in Rodents
Emil Egecioglu,Elisabet Jerlhag,Nicolas Salomé,Karolina P. Skibicka,David Haage,Mohammad Bohlooly-Y,Daniel Andersson,Mikael Bjursell,Daniel Perrissoud,Jörgen A. Engel,Suzanne L. Dickson +10 more
TL;DR: This article investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food.
Journal ArticleDOI
Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
TL;DR: The data indicate that ghrelin plays an important role in motivation and reinforcement for sucrose and impacts on the expression of dopamine and acetylcholine encoding genes in the mesolimbic reward circuitry, suggesting that gh Relin antagonists have therapeutic potential for the treatment of obesity and to suppress the overconsumption of sweet food.
Journal ArticleDOI
The role of the central ghrelin system in reward from food and chemical drugs
Suzanne L. Dickson,Emil Egecioglu,Sara Landgren,Karolina P. Skibicka,Jörgen A. Engel,Elisabet Jerlhag +5 more
TL;DR: The central ghrelin signalling system interfaces neurobiological circuits involved in reward from food as well as chemical drugs; agents that directly or indirectly suppress this system emerge as potential candidate drugs for suppressing problematic over-eating that leads to obesity as wellAs for the treatment of substance use disorder.
Journal ArticleDOI
Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference.
TL;DR: The data suggest that the central ghrelin signaling system constitutes a novel potential target for treatment of addictive behaviours such as drug dependence, and appears to be required not only for alcohol-induced reward, but also for reward induced by psychostimulant drugs.
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Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
Journal ArticleDOI
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
TL;DR: The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelIn, a peptide specifically releases GH both in vivo and in vitro.
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Ghrelin induces adiposity in rodents.
TL;DR: It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.
Journal ArticleDOI
A role for ghrelin in the central regulation of feeding.
Masamitsu Nakazato,Noboru Murakami,Yukari Date,Masayasu Kojima,Hisayuki Matsuo,Kenji Kangawa,Shigeru Matsukura +6 more
TL;DR: It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Journal ArticleDOI
A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans
David E. Cummings,Jonathan Q. Purnell,R. Scott Frayo,Karin Schmidova,Brent E. Wisse,David S. Weigle +5 more
TL;DR: The hypothesis that ghrelin plays a physiological role in meal initiation in humans is supported by the clear preprandials rise and postprandial fall in plasma ghrelIn levels.