Journal ArticleDOI
Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis.
Oliver Weingärtner,Nadja Weingärtner,Bruno Scheller,Dieter Lütjohann,Stefan Gräber,Hans-Joachim Schäfers,Michael Böhm,Ulrich Laufs +7 more
Reads0
Chats0
TLDR
Enhanced absorption and reduced synthesis of cholesterol is related to a positive family history of cardiovascular diseases and the development of concomitant CAD in patients with AS.Abstract:
ObjectiveHypercholesterolemia is a risk factor for aortic stenosis (AS) and for coronary artery disease (CAD). Serum cholesterol concentrations are determined by intestinal cholesterol absorption and endogenous cholesterol synthesis. Vascular effects of differences in cholesterol metabolism in patieread more
Citations
More filters
Journal ArticleDOI
Plant sterols and cardiovascular disease: a systematic review and meta-analysis.
Bernd Genser,Bernd Genser,Günther Silbernagel,Guy De Backer,Eric Bruckert,Rafael Carmena,M. John Chapman,John E. Deanfield,Olivier S. Descamps,Ernst Rietzschel,Karen C. Dias,Winfried März,Winfried März,Winfried März +13 more
TL;DR: A systematic review and meta-analysis of studies published between January 1950 and April 2010 did not reveal any evidence of an association between serum concentrations of plant sterols and risk of CVD.
Journal ArticleDOI
Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"
Jogchum Plat,Sabine Baumgartner,Tim Vanmierlo,Dieter Lütjohann,Kara L. Calkins,Douglas G. Burrin,Gregory Guthrie,Carel Thijs,A.A. Te Velde,Anita Vreugdenhil,Ronit Sverdlov,Johan Garssen,Kristiaan Wouters,Elke A. Trautwein,Tim G. A. M. Wolfs,C. van Gorp,Monique T. Mulder,Niels P. Riksen,Albert K. Groen,Ronald P. Mensink +19 more
TL;DR: Potential effects ranging from its presence and function intrauterine and in breast milk towards a potential role in the development of non-alcoholic steatohepatitis, cardiovascular disease (CVD), inflammatory bowel diseases (IBD) and allergic asthma are discussed.
Journal ArticleDOI
Implementing Phytosterols Into Medical Practice as a Cholesterol-Lowering Strategy: Overview of Efficacy, Effectiveness, and Safety
TL;DR: This review discusses the present knowledge that exists about the ability for therapeutic dosages of PSs to confer protection from cardiovascular-related mortality and morbidity and summarizes the factors that affect PS efficacy and the Canadian regulations that govern the use ofPSs as cholesterol-lowering agents in foods and supplements.
Journal ArticleDOI
Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men.
TL;DR: Higher serum plant sterol levels in middle-aged men predicted lower long-term mortality risk, possibly reflecting an association between higher synthesis/lower absorption of cholesterol and mortality.
Journal ArticleDOI
Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk
TL;DR: There is accumulating evidence that lower hepatic synthesis and higher intestinal absorption markers are associated with increased cardiovascular risk, and prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment.
References
More filters
Journal ArticleDOI
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
Journal Article
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
Anders G. Olsson,Jjv McMurray,Gudmundur Thorgeirsson,C Spaulding,J Slattery,Kalevi Pyörälä,Ole Faergeman,RA Wright,Kåre Berg,Lars Wilhelmsen,Terje R. Pedersen,Tatu A. Miettinen,Harvey D. White,John Kjekshus,Michael Gnant +14 more
Journal ArticleDOI
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
J Ames S Hepherd,S Tuart M. C Obbe,I An F Ord,C Hristopher G. I Sles,A. R Oss L Orimer,P Eter W. M Acfarlane,J Ames H. M C K Illop,C Hristopher J. P Ackard,S Tudy G Roup +8 more
TL;DR: In this article, a double-blind study was designed to determine whether the administration of pravastatin to men with hypercho-lesterolemia and no history of myocardial infarction correlated with the combined incidence of nonfatal mycardial in-farction and death from coronary heart disease.
Journal ArticleDOI
A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association
William G. Austen,JE Edwards,RL Frye,GG Gensini,Vincent L. Gott,LS Griffith,Dwight C. McGoon,ML Murphy,BB Roe +8 more