Journal ArticleDOI
An Immortal Cell Culture Model of Hypothalamic Gonadotropin-Releasing Hormone Neurons
Pamela L. Mellon,Satish A. Eraly,Denise D. Belsham,Mark A. Lawson,Melody E. Clark,David B. Whyte,Jolene J. Windle +6 more
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TLDR
The GT1 cell lines serve as an excellent model for molecular, pharmacological, electrophysiological, and biochemical investigations into the regulation of GnRH and the characteristics of a pure CNS neuronal population.About:
This article is published in Methods.The article was published on 1995-06-01. It has received 21 citations till now. The article focuses on the topics: Gonadotropin-releasing hormone & Hypothalamic Hormones.read more
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Journal ArticleDOI
The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer.
Melody E. Clark,Pamela L. Mellon +1 more
TL;DR: In this paper, the authors derived cell lines from tumors created in transgenic mice by targeting simian virus 40 T antigen expression by using the regulatory regions of the gene for gonadotropin-releasing hormone (GnRH), released from specialized neurons in the hypothalamus.
Journal ArticleDOI
Physiological relevance and functional potential of central nervous system-derived cell lines.
TL;DR: This article details recent progress in those cell lines that have enabled novel insight into the mechanisms controlling neuronal cell lineage choice and differentiation, both in vitro and in vivo.
Journal ArticleDOI
GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene.
TL;DR: It is shown that members of the GATA family of transcription factors regulate GnRH transcription through two GATA factor-binding motifs that occur in a tandem repeat within the GnRH neuron-specific enhancer.
Journal ArticleDOI
N-formylkynurenine as a marker of high light stress in photosynthesis.
TL;DR: The results are consistent with a role for the CP43 NFK modification in photoinhibition, the product formed from reaction of tryptophan with singlet oxygen, which can be produced under high light stress in PSII.
Journal ArticleDOI
Posttranslational modifications in the CP43 subunit of photosystem II
Lorraine B. Anderson,Melissa Maderia,Melissa Maderia,Anthony J. A. Ouellette,Anthony J. A. Ouellette,Cindy Putnam-Evans,LeeAnn Higgins,Thomas P. Krick,Michael J. MacCoss,Hanjo Lim,John R. Yates,Bridgette A. Barry +11 more
TL;DR: It is hypothesize that Trp-352 oxidative modifications are a byproduct of PSII water-splitting or electron transfer reactions and that these modifications target PSII for turnover.