Journal ArticleDOI
An overview on chemical aspects and potential health benefits of limonoids and their derivatives.
TLDR
The aim of this review article is to discuss the recent developments on limonoids chemical aspects and biological activities with the relationship between structure and activity, supporting the new possibilities for the medicinal and/or nutraceutical use of these compounds.Abstract:
Limonoids are heavily oxygenated, modified triterpenes dominant in Meliaceae and Rutaceae plant families. The term 'limonoid' is derived from limonin, which was first identified as the bitter constituent of Citrus seeds in 1841. This group of secondary metabolites exhibits a wide range of biological properties, including anticancer, antibacterial, antifungal, antimalarial, and antiviral activities. Significant progress on the role of limonoids as promising candidates for cancer chemoprevention and/or therapy has been achieved in particular in recent years. The aim of this review article is to discuss the recent developments on limonoids chemical aspects and biological activities with the relationship between structure and activity, supporting the new possibilities for the medicinal and/or nutraceutical use of these compounds.read more
Citations
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Journal ArticleDOI
The Chemistry and Pharmacology of Citrus Limonoids
TL;DR: The chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach, and synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis.
Journal ArticleDOI
Chemistry and health effects of furanocoumarins in grapefruit
TL;DR: It is suggested furanocoumarins may serve as bioactive components that contribute, at least in part, to the health benefits of grapefruit.
Journal ArticleDOI
Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).
TL;DR: The patents reported in this review showed that the interest in this field is constant and mainly devoted to the study of selective MAO-B inhibitors, used as drugs for the treatment of neurological disorders.
Journal ArticleDOI
Recent progress in the chemistry and biology of limonoids
Yuanyuan Zhang,Hui Xu +1 more
TL;DR: This review covers the isolation and structure determination of limonoids reported during 2014–2016 (with 363 new compounds in 68 papers), together with the relevant biological activities and source organisms.
Journal ArticleDOI
Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities
Yu-Sheng Shi,Yu-Sheng Shi,Yan Zhang,Hao-Tian Li,Chuanhai Wu,Hesham R. El-Seedi,Hesham R. El-Seedi,Wen-Kang Ye,Wen-Kang Ye,Zi-Wei Wang,Chun-Bin Li,Xu-Fu Zhang,Guoyin Kai +12 more
TL;DR: Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus and are proved to be the leading cause of bitterness in Citrus fruits.
References
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PCNA, the Maestro of the Replication Fork
TL;DR: Proliferating cell nuclear antigen -a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork, indicating that these interactions do not occur simultaneously during replication.
Journal ArticleDOI
Antioxidants in fruits and vegetables – the millennium’s health
Charanjit Kaur,H. C. Kapoor +1 more
TL;DR: The potential of fruits and vegetables rich in antioxidants, their health benefits and the eAect of processing on the bioavailability of these nutrients have been highlighted in this article, where some of the important methods used to determine the antioxidant activity.
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Limonoids: Overview of significant bioactive triterpenes distributed in plants kingdom
Amit Roy,Shailendra Saraf +1 more
TL;DR: Limonoids are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton and their occurrence in the plant kingdom is confined to only plant families of order Rutales.
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Antioxidant Activity of Citrus Limonoids, Flavonoids, and Coumarins
TL;DR: It seems that flavonoids, which contain a chromanol ring system, had stronger antioxidant activity as compared to limonoids and bergapten, which lack the hydroxy groups.
Journal ArticleDOI
NF-κB and virus infection: who controls whom
TL;DR: This review summarizes what is known about the control of NF‐κB by viruses, and discusses the possible outcome of NF-κB activation during viral infection, which may benefit either the host or the pathogen.
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Limonoids: Overview of significant bioactive triterpenes distributed in plants kingdom
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